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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Jejunal transport properties of piebald mouse model for Hirschsprung's disease.

Unidirectional fluxes of alanine, methionine, and Na were measured in jejunal segments from 3- to 4-wk-old normal (N) mice or mice with congenital (P) or induced (I) megacolon in the absence of electrochemical gradients. Short-circuit currents were 286.8 +/- 16.3 and 302.1 +/- 32.6 mu A/cm2 for P and I mice, respectively, and were approximately 1.5-2 times greater than in N mice. Tissue conductances averaged 42.3 +/- 0.6 and 39.3 +/- 3.4 mS/cm2 for P and I mice, respectively, and were twice those found in N mice. Net Na absorption was 2-3 times greater in P than N mice and was increased by addition of alanine. Alanine and methionine were actively absorbed and the net fluxes of alanine were 2-3 times greater in p and I mice than in normals. Unidirectional alanine influx was enhanced in P and I mice. Jmax of 9.7 +/- 2.6 and 14.2 +/- 1.0 micro M x cm-2 x h-1 were obtained for N and P mice, respectively. These results show that the transport properties of jejunal mucosa of mice with megacolon differ from those of N mice. Mice with megacolon absorb alanine and Na at a greater rate than N mice and the enhanced amino acid absorptive rate can be explained by an increased alanine influx, probably due to an increased number of active transport carriers.[1]


  1. Jejunal transport properties of piebald mouse model for Hirschsprung's disease. Cooke, H.J., Henning, H.J., Wood, J.D., Cooke, A.R. Am. J. Physiol. (1980) [Pubmed]
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