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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11.

The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.[1]

References

  1. Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Kou, K., James, P.L., Clemmons, D.R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Rotwein, P. Genomics (1994) [Pubmed]
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