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Gene Review

Igfbp1  -  insulin-like growth factor binding protein 1

Mus musculus

Synonyms: IBP-1, IGF-binding protein 1, IGFBP-1, Igfbp-1, Insulin-like growth factor-binding protein 1
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Disease relevance of Igfbp1


Psychiatry related information on Igfbp1


High impact information on Igfbp1


Chemical compound and disease context of Igfbp1


Biological context of Igfbp1


Anatomical context of Igfbp1


Associations of Igfbp1 with chemical compounds

  • Three lactogenic hormones (insulin, 154 nM; prolactin, 4.3 nM; and cortisol, 1.4 microM) in all combinations were tested to determine their effects on IGFBP secretion [15].
  • Strikingly different patterns of IGFBP immunolocalization were observed between control and dexamethasone-treated animals [19].
  • Here we examine IGFBP expression during regression of androgen-dependent Shionogi carcinoma tumors after castration [20].
  • Insulin-like growth factor binding proteins (IGFBPs) -3 and -5 are known to interact with various components of the extracellular matrix (ECM; e.g. heparin and heparan sulphate) and this interaction is believed to affect the affinity of both IGFBP species for their cognate ligands--IGF-I and -II [21].
  • In general, these data support the prediction made that chronically elevated exposure to IGF-I in IGF-I transgenic mice renders them less susceptible to the effects of ethanol than their non-transgenic siblings, and that overexpression of IGF binding protein 1 has the opposite effect [22].

Physical interactions of Igfbp1

  • The IGF binding proteins (IGFBP's) showed weak mRNA expression for IGFBP-1 and -6 [23].

Enzymatic interactions of Igfbp1

  • These findings have functional significance since alpha(2)M protects IGFBP-1 from proteolysis and abrogates the inhibitory effect of phosphorylated IGFBP-1 on IGF-I stimulated 3T3-L1 cell proliferation [24].

Regulatory relationships of Igfbp1


Other interactions of Igfbp1


Analytical, diagnostic and therapeutic context of Igfbp1


  1. Interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) regulate insulin-like growth factor binding protein-1 (IGFBP-1) levels and mRNA abundance in vivo and in vitro. Benbassat, C.A., Lazarus, D.D., Cichy, S.B., Evans, T.M., Moldawer, L.L., Lowry, S.F., Unterman, T.G. Horm. Metab. Res. (1999) [Pubmed]
  2. Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice. Rajkumar, K., Krsek, M., Dheen, S.T., Murphy, L.J. J. Clin. Invest. (1996) [Pubmed]
  3. Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Adhami, V.M., Siddiqui, I.A., Ahmad, N., Gupta, S., Mukhtar, H. Cancer Res. (2004) [Pubmed]
  4. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. Butt, A.J., Dickson, K.A., McDougall, F., Baxter, R.C. J. Biol. Chem. (2003) [Pubmed]
  5. Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins. Boers, W., Aarrass, S., Linthorst, C., Pinzani, M., Elferink, R.O., Bosma, P. J. Biol. Chem. (2006) [Pubmed]
  6. Expression of insulin-like growth factor binding proteins (IGFBPs) in IGFBP-1 transgenic mice. Huang, H., Rajkumar, K., Murphy, L.J. J. Endocrinol. (1997) [Pubmed]
  7. Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. Leu, J.I., Crissey, M.A., Taub, R. J. Clin. Invest. (2003) [Pubmed]
  8. Polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice. Van den Berg, C.L., Cox, G.N., Stroh, C.A., Hilsenbeck, S.G., Weng, C.N., McDermott, M.J., Pratt, D., Osborne, C.K., Coronado-Heinsohn, E.B., Yee, D. Eur. J. Cancer (1997) [Pubmed]
  9. Hyperglycemia and impaired glucose tolerance in IGF binding protein-1 transgenic mice. Rajkumar, K., Dheen, S.T., Murphy, L.J. Am. J. Physiol. (1996) [Pubmed]
  10. Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Kou, K., James, P.L., Clemmons, D.R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Rotwein, P. Genomics (1994) [Pubmed]
  11. Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice. Salih, D.A., Tripathi, G., Holding, C., Szestak, T.A., Gonzalez, M.I., Carter, E.J., Cobb, L.J., Eisemann, J.E., Pell, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  12. The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo. Oliver, W.T., Rosenberger, J., Lopez, R., Gomez, A., Cummings, K.K., Fiorotto, M.L. Endocrinology (2005) [Pubmed]
  13. PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice. Christians, J.K., Hoeflich, A., Keightley, P.D. Genetics (2006) [Pubmed]
  14. Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis. Fornoni, A., Rosenzweig, S.A., Lenz, O., Rivera, A., Striker, G.E., Elliot, S.J. Endocrinology (2006) [Pubmed]
  15. Regulation of insulin-like growth factor binding protein secretion by a murine mammary epithelial cell line. Skaar, T.C., Baumrucker, C.R. Exp. Cell Res. (1993) [Pubmed]
  16. Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis. Boney, C.M., Moats-Staats, B.M., Stiles, A.D., D'Ercole, A.J. Endocrinology (1994) [Pubmed]
  17. Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland. Allar, M.A., Wood, T.L. Endocrinology (2004) [Pubmed]
  18. Characterization of insulin-like growth factor binding proteins (IGFBP) and regulation of IGFBP-4 in bone marrow stromal cells. Grellier, P., Yee, D., Gonzalez, M., Abboud, S.L. Br. J. Haematol. (1995) [Pubmed]
  19. Dexamethasone changes the composition of insulin-like growth factor binding proteins in the newborn mouse ileum. Gordon, P.V., Moats-Staats, B.M., Stiles, A.D., Price, W.A. J. Pediatr. Gastroenterol. Nutr. (2002) [Pubmed]
  20. Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins. Nickerson, T., Miyake, H., Gleave, M.E., Pollak, M. Cancer Res. (1999) [Pubmed]
  21. Molecular recognition characteristics in the insulin-like growth factor (IGF)-insulin-like growth factor binding protein -3/5 (IGFBP-3/5) heparin axis. Beattie, J., Phillips, K., Shand, J.H., Szymanowska, M., Flint, D.J., Allan, G.J. J. Mol. Endocrinol. (2005) [Pubmed]
  22. Insulin-like growth factor I expression alters acute sensitivity and tolerance to ethanol in transgenic mice. Pucilowski, O., Ayensu, W.K., D'Ercole, A.J. Eur. J. Pharmacol. (1996) [Pubmed]
  23. Gene expression of the insulin-like growth factor system during mouse kidney development. Lindenbergh-Kortleve, D.J., Rosato, R.R., van Neck, J.W., Nauta, J., van Kleffens, M., Groffen, C., Zwarthoff, E.C., Drop, S.L. Mol. Cell. Endocrinol. (1997) [Pubmed]
  24. alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis. Westwood, M., Aplin, J.D., Collinge, I.A., Gill, A., White, A., Gibson, J.M. J. Biol. Chem. (2001) [Pubmed]
  25. Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice. Lewitt, M.S., Brismar, K., Wang, J., Wivall-Helleryd, I.L., Sindelar, P., Gonzalez, F.J., Bergman, T., Bobek, G.A. Growth Horm. IGF Res. (2001) [Pubmed]
  26. Purification from transformed mouse fibroblast of a cell growth inhibitor which is an IGF-binding protein. Blat, C., Villaudy, J., Delbé, J., Troalen, F., Golde, A., Harel, L. Growth Factors (1992) [Pubmed]
  27. IGFBP-1 inhibits EGF mitogenic activity in cultured endometrial stromal cells. Cavaillé, F., Neau, E., Vouters, M., Bry-Gauillard, H., Colombel, A., Milliez, J., Le Bouc, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  28. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. Sinha, D., Wang, Z., Ruchalski, K.L., Levine, J.S., Krishnan, S., Lieberthal, W., Schwartz, J.H., Borkan, S.C. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  29. A quantitative RT-PCR study of the mRNA expression profile of the IGF axis during mammary gland development. Boutinaud, M., Shand, J.H., Park, M.A., Phillips, K., Beattie, J., Flint, D.J., Allan, G.J. J. Mol. Endocrinol. (2004) [Pubmed]
  30. Dose-response effects of a new growth hormone receptor antagonist (B2036-PEG) on circulating, hepatic and renal expression of the growth hormone/insulin-like growth factor system in adult mice. van Neck, J.W., Dits, N.F., Cingel, V., Hoppenbrouwers, I.A., Drop, S.L., Flyvbjerg, A. J. Endocrinol. (2000) [Pubmed]
  31. Electrical stimulation modulates IGF binding protein transcript levels in C2C12 myotubes. Bayol, S., Brownson, C., Loughna, P.T. Cell Biochem. Funct. (2005) [Pubmed]
  32. Characterization of insulin-like growth factor binding proteins (IGFBPs) during gestation in mice: effects of hypophysectomy and an IGFBP-specific serum protease activity. Fielder, P.J., Thordarson, G., Talamantes, F., Rosenfeld, R.G. Endocrinology (1990) [Pubmed]
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