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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Production and function of IL-10 in the central nervous system.

Our data suggest an important regulatory role for IL-10 within the central nervous system by a) reducing the antigenpresenting capacity of astro- and microglia and thereby lowering or preventing, antigen-specific proliferative T cell responses, and b) inhibition of inflammatory cytokine production by the resident parenchymal cells as well as from infiltrating monocytes/macrophages. In the latter instance the signals triggering cytokine production are crucial since IL-10 interferes with bacterial but not viral or cytokine-induced activation of expression of cytokine genes.[1]

References

  1. Production and function of IL-10 in the central nervous system. Frei, K., Lins, H., Fontana, A. Schweizer Archiv für Neurologie und Psychiatrie (Zurich, Switzerland : 1985) (1994) [Pubmed]
 
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