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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Generation and characterization of a delta F508 cystic fibrosis mouse model.

We have generated mice carrying the most common mutation in cystic fibrosis ( CF), delta F508, within the cystic fibrosis (Cftr) gene. Mutant animals show pathological and electrophysiological changes consistent with a CF phenotype. delta F508-/- mice die from peritonitis and show deficiencies in cAMP-activated electrogenic Cl- transport. These mice produce delta F508 transcripts and show the temperature-dependent trafficking defect first described for the human delta F508 CFTR protein. A functional CFTR Cl- channel not demonstrated by null CF mice or present at 37 degrees C was detected following incubation of epithelial cells at 27 degrees C. Thus, these mice are an accurate delta F508 model and will be valuable for testing drugs aimed at overcoming the delta F508 trafficking defect.[1]


  1. Generation and characterization of a delta F508 cystic fibrosis mouse model. Colledge, W.H., Abella, B.S., Southern, K.W., Ratcliff, R., Jiang, C., Cheng, S.H., MacVinish, L.J., Anderson, J.R., Cuthbert, A.W., Evans, M.J. Nat. Genet. (1995) [Pubmed]
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