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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Peritonitis


Psychiatry related information on Peritonitis


High impact information on Peritonitis

  • Peritonitis due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus peritonitis associated with dialysis [7].
  • Mutant animals show pathological and electrophysiological changes consistent with a CF phenotype. delta F508-/- mice die from peritonitis and show deficiencies in cAMP-activated electrogenic Cl- transport [8].
  • Here we show that mice deficient in Ang-2 (encoded by the gene Angpt2) cannot elicit an inflammatory response in thioglycollate-induced or Staphylococcus aureus-induced peritonitis, or in the dorsal skinfold chamber model [9].
  • Here we show that such inflammation requires the forkhead transcription factor Foxo3a: Foxo3a-deficient mice are resistant to two models of neutrophilic inflammation, immune complex-mediated inflammatory arthritis and thioglycollate-induced peritonitis [10].
  • Subsequent optimization of the statins for LFA-1 binding resulted in potent, selective and orally active LFA-1 inhibitors that suppress the inflammatory response in a murine model of peritonitis [11].

Chemical compound and disease context of Peritonitis


Biological context of Peritonitis


Anatomical context of Peritonitis


Gene context of Peritonitis

  • Thus, Stat6-/- and Stat4-/- mice appeared to be resistant to septic peritonitis by enhancing local bacterial clearance and modulating systemic organ damage, respectively, via balancing cytokine responses [17].
  • Furthermore, the minimum effective dose of Crry-Ig significantly enhanced susceptibility to infection in a mouse model of acute septic peritonitis, whereas the effect of CR2-Crry on susceptibility to infection was indistinguishable from that of PBS control [26].
  • It has recently been shown that high concentrations of recombinant LBP can protect mice in a peritonitis model from the lethal effects of LPS [27].
  • Here we report that LBP KO mice are more susceptible to Salmonella peritonitis, but not to oral or i.v. infection [28].
  • Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis [29].

Analytical, diagnostic and therapeutic context of Peritonitis


  1. Mapping of a gene causing familial Mediterranean fever to the short arm of chromosome 16. Pras, E., Aksentijevich, I., Gruberg, L., Balow, J.E., Prosen, L., Dean, M., Steinberg, A.D., Pras, M., Kastner, D.L. N. Engl. J. Med. (1992) [Pubmed]
  2. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Calandra, T., Echtenacher, B., Roy, D.L., Pugin, J., Metz, C.N., Hültner, L., Heumann, D., Männel, D., Bucala, R., Glauser, M.P. Nat. Med. (2000) [Pubmed]
  3. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. Turnbull, I.R., McDunn, J.E., Takai, T., Townsend, R.R., Cobb, J.P., Colonna, M. J. Exp. Med. (2005) [Pubmed]
  4. Conversion of a poorly differentiated human adenocarcinoma to ascites form with invasion and metastasis in nude mice. Takahashi, S., Konishi, Y., Nakatani, K., Inui, S., Kojima, K., Shiratori, T. J. Natl. Cancer Inst. (1978) [Pubmed]
  5. Osmotic agents and buffers in peritoneal dialysis solution: monocyte cytokine release and in vitro cytotoxicity. Plum, J., Schoenicke, G., Grabensee, B. Am. J. Kidney Dis. (1997) [Pubmed]
  6. Management of intra-abdominal infections. The case for intraoperative cultures and comprehensive broad-spectrum antibiotic coverage. The Canadian Intra-abdominal Infection Study Group. Christou, N.V., Turgeon, P., Wassef, R., Rotstein, O., Bohnen, J., Potvin, M. Archives of surgery (Chicago, Ill. : 1960) (1996) [Pubmed]
  7. Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. Smith, T.L., Pearson, M.L., Wilcox, K.R., Cruz, C., Lancaster, M.V., Robinson-Dunn, B., Tenover, F.C., Zervos, M.J., Band, J.D., White, E., Jarvis, W.R. N. Engl. J. Med. (1999) [Pubmed]
  8. Generation and characterization of a delta F508 cystic fibrosis mouse model. Colledge, W.H., Abella, B.S., Southern, K.W., Ratcliff, R., Jiang, C., Cheng, S.H., MacVinish, L.J., Anderson, J.R., Cuthbert, A.W., Evans, M.J. Nat. Genet. (1995) [Pubmed]
  9. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N.W., Witzenrath, M., Rosseau, S., Suttorp, N., Sobke, A., Herrmann, M., Preissner, K.T., Vajkoczy, P., Augustin, H.G. Nat. Med. (2006) [Pubmed]
  10. Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Jonsson, H., Allen, P., Peng, S.L. Nat. Med. (2005) [Pubmed]
  11. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y., Hommel, U. Nat. Med. (2001) [Pubmed]
  12. Treatment of Torulopsis glabrata peritonitis with intraperitoneal amphotericin B. Rahko, P.S., Davey, W.P., Wheat, L.J., Bartlett, M. JAMA (1983) [Pubmed]
  13. Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. Haribabu, B., Verghese, M.W., Steeber, D.A., Sellars, D.D., Bock, C.B., Snyderman, R. J. Exp. Med. (2000) [Pubmed]
  14. Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. Sevransky, J.E., Shaked, G., Novogrodsky, A., Levitzki, A., Gazit, A., Hoffman, A., Elin, R.J., Quezado, Z.M., Freeman, B.D., Eichacker, P.Q., Danner, R.L., Banks, S.M., Bacher, J., Thomas, M.L., Natanson, C. J. Clin. Invest. (1997) [Pubmed]
  15. Gentamicin for treatment of peritonitis in continuous ambulatory peritoneal dialysis. de Paepe, M., Belpaire, F., Bogaert, M., Lameire, N., Ringoir, S. Lancet (1981) [Pubmed]
  16. Randomized, comparative study of oral ofloxacin versus intravenous cefotaxime in spontaneous bacterial peritonitis. Navasa, M., Follo, A., Llovet, J.M., Clemente, G., Vargas, V., Rimola, A., Marco, F., Guarner, C., Forné, M., Planas, R., Bañares, R., Castells, L., Jimenez De Anta, M.T., Arroyo, V., Rodés, J. Gastroenterology (1996) [Pubmed]
  17. Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. Matsukawa, A., Kaplan, M.H., Hogaboam, C.M., Lukacs, N.W., Kunkel, S.L. J. Exp. Med. (2001) [Pubmed]
  18. Risk of a first community-acquired spontaneous bacterial peritonitis in cirrhotics with low ascitic fluid protein levels. Guarner, C., Solà, R., Soriano, G., Andreu, M., Novella, M.T., Vila, M.C., Sàbat, M., Coll, S., Ortiz, J., Gómez, C., Balanzó, J. Gastroenterology (1999) [Pubmed]
  19. Venous admixture in human septic shock: comparative effects of blood volume expansion, dopamine infusion and isoproterenol infusion on mismatching of ventilation and pulmonary blood flow in peritonitis. Jardin, F., Eveleigh, M.C., Gurdjian, F., Delille, F., Margairaz, A. Circulation (1979) [Pubmed]
  20. The diagnosis of bacterial peritonitis: comparison of pH, lactate concentration and leukocyte count. Garcia-Tsao, G., Conn, H.O., Lerner, E. Hepatology (1985) [Pubmed]
  21. Continuous versus inpatient prophylaxis of the first episode of spontaneous bacterial peritonitis with norfloxacin. Novella, M., Solà, R., Soriano, G., Andreu, M., Gana, J., Ortiz, J., Coll, S., Sàbat, M., Vila, M.C., Guarner, C., Vilardell, F. Hepatology (1997) [Pubmed]
  22. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Labow, M.A., Norton, C.R., Rumberger, J.M., Lombard-Gillooly, K.M., Shuster, D.J., Hubbard, J., Bertko, R., Knaack, P.A., Terry, R.W., Harbison, M.L. Immunity (1994) [Pubmed]
  23. Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids. Waring, P., Wycherley, K., Cary, D., Nicola, N., Metcalf, D. J. Clin. Invest. (1992) [Pubmed]
  24. Diagnostic paracentesis. A potent clinical tool. Hoefs, J.C. Gastroenterology (1990) [Pubmed]
  25. Nitric oxide production by peritoneal macrophages of cirrhotic rats: a host response against bacterial peritonitis. Morales-Ruiz, M., Jiménez, W., Ros, J., Solé, M., Leivas, A., Bosch-Marcé, M., Rivera, F., Arroyo, V., Rodés, J. Gastroenterology (1997) [Pubmed]
  26. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. Atkinson, C., Song, H., Lu, B., Qiao, F., Burns, T.A., Holers, V.M., Tsokos, G.C., Tomlinson, S. J. Clin. Invest. (2005) [Pubmed]
  27. High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes. Zweigner, J., Gramm, H.J., Singer, O.C., Wegscheider, K., Schumann, R.R. Blood (2001) [Pubmed]
  28. The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. Fierer, J., Swancutt, M.A., Heumann, D., Golenbock, D. J. Immunol. (2002) [Pubmed]
  29. Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis. Kanamaru, Y., Sumiyoshi, K., Ushio, H., Ogawa, H., Okumura, K., Nakao, A. J. Immunol. (2005) [Pubmed]
  30. Renal impairment after spontaneous bacterial peritonitis in cirrhosis: incidence, clinical course, predictive factors and prognosis. Follo, A., Llovet, J.M., Navasa, M., Planas, R., Forns, X., Francitorra, A., Rimola, A., Gassull, M.A., Arroyo, V., Rodés, J. Hepatology (1994) [Pubmed]
  31. Ciprofloxacin and long-term prevention of spontaneous bacterial peritonitis: results of a prospective controlled trial. Rolachon, A., Cordier, L., Bacq, Y., Nousbaum, J.B., Franza, A., Paris, J.C., Fratte, S., Bohn, B., Kitmacher, P., Stahl, J.P. Hepatology (1995) [Pubmed]
  32. Is the acidity of ascitic fluid a reliable index in making the presumptive diagnosis of spontaneous bacterial peritonitis? Pinzello, G., Virdone, R., Lojacono, F., Ciambra, M., Dardanoni, G., Fiorentino, G., Riccobono, L., Pagliaro, L. Hepatology (1986) [Pubmed]
  33. Kinetics of phospholipase A2, arachidonic acid, and eicosanoid appearance in mouse zymosan peritonitis. Lundy, S.R., Dowling, R.L., Stevens, T.M., Kerr, J.S., Mackin, W.M., Gans, K.R. J. Immunol. (1990) [Pubmed]
  34. Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice. Szántó, S., Bárdos, T., Gál, I., Glant, T.T., Mikecz, K. Arthritis Rheum. (2004) [Pubmed]
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