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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Deleted in oral cancer-1 ( doc-1), a novel oral tumor suppressor gene.

We have identified, isolated, and partially characterized doc-1, a novel cDNA sequence whose activity is consistent with a suppressor of hamster oral carcinogenesis. Doc-1 is an evolutionarily conserved gene exhibiting loss of heterozygosity and marked reduction in expression in malignant hamster oral keratinocytes. The full-length doc-1 cDNA encodes an 87 amino acid product that shows a significant homology to one of the seven novel genes induced in mouse fibroblasts by TNF-alpha. Transfection of the full-length doc-1 cDNA into malignant hamster oral keratinocytes alters the behavior of the recipients in terms of morphology, growth rate, and anchorage-independent growth, suggesting reversion of transformation phenotypes. We propose that doc-1 is a novel tumor suppressor gene in oral cancer development.[1]

References

  1. Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene. Todd, R., McBride, J., Tsuji, T., Donoff, R.B., Nagai, M., Chou, M.Y., Chiang, T., Wong, D.T. FASEB J. (1995) [Pubmed]
 
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