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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Wavelength specificity of photoparoxysmal responses in idiopathic generalized epilepsy.

Using optic filters, we analyzed the wave-length specificity of photoparoxysmal responses ( PPR) in photosensitive patients with idiopathic generalized epilepsy (IGE). We specified the wavelength spectrum approximately 700 nm (660-720 nm) as the only visible spectrum essential for eliciting PPR in some normal trichromat IGE patients and showed that any flashing lights containing this essential wavelength spectrum could elicit PPR independent of the number of stimulated cones. Absorption of the wavelength spectrum approximately 700 nm by optic filters eliminated PPR in normal trichromat IGE patients. In an IGE patient with deuteranomaly, intermittent flashing lights containing a part of the wavelength spectrum from 580 to 700 nm elicited PPR. These data suggest a new interpretation of wavelength specificity of PPR: Flashing lights containing the wavelength spectrum that does not produce antagonistic cone interactions at the level of retinal ganglion cells can elicit PPR in some photosensitive IGE patients.[1]

References

  1. Wavelength specificity of photoparoxysmal responses in idiopathic generalized epilepsy. Takahashi, Y., Fujiwara, T., Yagi, K., Seino, M. Epilepsia (1995) [Pubmed]
 
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