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MeSH Review

Epilepsy, Generalized

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Gene context of Epilepsy, Generalized


Analytical, diagnostic and therapeutic context of Epilepsy, Generalized


  1. De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy. Claes, L., Del-Favero, J., Ceulemans, B., Lagae, L., Van Broeckhoven, C., De Jonghe, P. Am. J. Hum. Genet. (2001) [Pubmed]
  2. Genome-wide linkage scan of epilepsy-related photoparoxysmal electroencephalographic response: evidence for linkage on chromosomes 7q32 and 16p13. Pinto, D., Westland, B., de Haan, G.J., Rudolf, G., da Silva, B.M., Hirsch, E., Lindhout, D., Trenité, D.G., Koeleman, B.P. Hum. Mol. Genet. (2005) [Pubmed]
  3. Review of valproate monotherapy in the treatment of generalized tonic-clonic seizures. Wilder, B.J., Rangel, R.J. Am. J. Med. (1988) [Pubmed]
  4. Association of mu-opioid receptor subunit gene and idiopathic generalized epilepsy. Wilkie, H., Osei-Lah, A., Chioza, B., Nashef, L., McCormick, D., Asherson, P., Makoff, A.J. Neurology (2002) [Pubmed]
  5. Evidence for distinct genetic influences on generalized and localization-related epilepsy. Winawer, M.R., Rabinowitz, D., Barker-Cummings, C., Scheuer, M.L., Pedley, T.A., Hauser, W.A., Ottman, R. Epilepsia (2003) [Pubmed]
  6. Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Haug, K., Warnstedt, M., Alekov, A.K., Sander, T., Ramírez, A., Poser, B., Maljevic, S., Hebeisen, S., Kubisch, C., Rebstock, J., Horvath, S., Hallmann, K., Dullinger, J.S., Rau, B., Haverkamp, F., Beyenburg, S., Schulz, H., Janz, D., Giese, B., Müller-Newen, G., Propping, P., Elger, C.E., Fahlke, C., Lerche, H., Heils, A. Nat. Genet. (2003) [Pubmed]
  7. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Cossette, P., Liu, L., Brisebois, K., Dong, H., Lortie, A., Vanasse, M., Saint-Hilaire, J.M., Carmant, L., Verner, A., Lu, W.Y., Wang, Y.T., Rouleau, G.A. Nat. Genet. (2002) [Pubmed]
  8. The genetics of human epilepsy. Scheffer, I.E., Berkovic, S.F. Trends Pharmacol. Sci. (2003) [Pubmed]
  9. Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. Kaupmann, K., Schuler, V., Mosbacher, J., Bischoff, S., Bittiger, H., Heid, J., Froestl, W., Leonhard, S., Pfaff, T., Karschin, A., Bettler, B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Sacred disease secrets revealed: the genetics of human epilepsy. Turnbull, J., Lohi, H., Kearney, J.A., Rouleau, G.A., Delgado-Escueta, A.V., Meisler, M.H., Cossette, P., Minassian, B.A. Hum. Mol. Genet. (2005) [Pubmed]
  11. Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders. Chadwick, D. Am. J. Med. (1988) [Pubmed]
  12. The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin. Lortie, A., Chiron, C., Mumford, J., Dulac, O. Neurology (1993) [Pubmed]
  13. Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies. Sander, T., Janz, D., Ramel, C., Ross, C.A., Paschen, W., Hildmann, T., Wienker, T.F., Bianchi, A., Bauer, G., Sailer, U. Neurology (1995) [Pubmed]
  14. Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. French, J.A., Kanner, A.M., Bautista, J., Abou-Khalil, B., Browne, T., Harden, C.L., Theodore, W.H., Bazil, C., Stern, J., Schachter, S.C., Bergen, D., Hirtz, D., Montouris, G.D., Nespeca, M., Gidal, B., Marks, W.J., Turk, W.R., Fischer, J.H., Bourgeois, B., Wilner, A., Faught, R.E., Sachdeo, R.C., Beydoun, A., Glauser, T.A. Epilepsia (2004) [Pubmed]
  15. Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies. Patsalos, P.N. Epilepsia (2005) [Pubmed]
  16. Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2). Gao, B., Sekido, Y., Maximov, A., Saad, M., Forgacs, E., Latif, F., Wei, M.H., Lerman, M., Lee, J.H., Perez-Reyes, E., Bezprozvanny, I., Minna, J.D. J. Biol. Chem. (2000) [Pubmed]
  17. Reciprocal up- and down-regulation of BDNF mRNA in tetanus toxin-induced epileptic focus and inhibitory surround in cerebral cortex. Liang, F., Le, L.D., Jones, E.G. Cereb. Cortex (1998) [Pubmed]
  18. Genetic association studies in epilepsy: "the truth is out there". Tan, N.C., Mulley, J.C., Berkovic, S.F. Epilepsia (2004) [Pubmed]
  19. Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor alpha 1 and gamma 2 subunit gene cluster on chromosome 5. Sander, T., Hildmann, T., Janz, D., Wienker, T.F., Bianchi, A., Bauer, G., Sailer, U., Scaramelli, A., Neitzel, H., Schmitz, B., Bailey, M.E., Beck-Mannagetta, G., Johnson, K.J., Darlison, M.G. Epilepsy Res. (1996) [Pubmed]
  20. Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies. Sobetzko, D., Sander, T., Becker, C.M. Am. J. Med. Genet. (2001) [Pubmed]
  21. The embryonic form of neural cell surface molecule (E-NCAM) in the rat hippocampus and its reexpression on glial cells following kainic acid-induced status epilepticus. Le Gal La Salle, G., Rougon, G., Valin, A. J. Neurosci. (1992) [Pubmed]
  22. Genital automatisms: a video-EEG study in patients with medically refractory seizures. Dobesberger, J., Walser, G., Unterberger, I., Embacher, N., Luef, G., Bauer, G., Benke, T., Bartha, L., Ulmer, H., Ortler, M., Trinka, E. Epilepsia (2004) [Pubmed]
  23. Wisconsin Card Sorting Test performance in patients with complex partial seizures of temporal-lobe origin. Hermann, B.P., Wyler, A.R., Richey, E.T. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1988) [Pubmed]
  24. PET: central benzodiazepine neuroreceptor mapping in generalized epilepsies. Savic, I. Advances in neurology. (2000) [Pubmed]
  25. Somatosensory evoked spikes and epileptic seizures: a study of 385 cases. Fonseca, L.C., Tedrus, G.M. Clinical EEG (electroencephalography). (2000) [Pubmed]
  26. Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. Lenzen, K.P., Heils, A., Lorenz, S., Hempelmann, A., Höfels, S., Lohoff, F.W., Schmitz, B., Sander, T. Epilepsy Res. (2005) [Pubmed]
  27. LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Ottman, R., Winawer, M.R., Kalachikov, S., Barker-Cummings, C., Gilliam, T.C., Pedley, T.A., Hauser, W.A. Neurology (2004) [Pubmed]
  28. GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. Dibbens, L.M., Feng, H.J., Richards, M.C., Harkin, L.A., Hodgson, B.L., Scott, D., Jenkins, M., Petrou, S., Sutherland, G.R., Scheffer, I.E., Berkovic, S.F., Macdonald, R.L., Mulley, J.C. Hum. Mol. Genet. (2004) [Pubmed]
  29. Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy. Tauer, U., Lorenz, S., Lenzen, K.P., Heils, A., Muhle, H., Gresch, M., Neubauer, B.A., Waltz, S., Rudolf, G., Mattheisen, M., Strauch, K., Nürnberg, P., Schmitz, B., Stephani, U., Sander, T. Ann. Neurol. (2005) [Pubmed]
  30. Genetics of the epilepsies. Gutierrez-Delicado, E., Serratosa, J.M. Curr. Opin. Neurol. (2004) [Pubmed]
  31. Feline generalized epilepsy induced by tranexamic acid (AMCA). Pellegrini, A., Giaretta, D., Chemello, R., Zanotto, L., Testa, G. Epilepsia (1982) [Pubmed]
  32. Magnetic resonance and biochemical studies during pentylenetetrazole-kindling development: the relationship between nitric oxide, neuronal nitric oxide synthase and seizures. Itoh, K., Watanabe, M., Yoshikawa, K., Kanaho, Y., Berliner, L.J., Fujii, H. Neuroscience (2004) [Pubmed]
  33. Time-dependent distribution and neuronal localization of c-fos protein in the rat hippocampus following 4-aminopyridine seizures. Mihály, A., Szakács, R., Bohata, C., Dobó, E., Krisztin-Péva, B. Epilepsy Res. (2001) [Pubmed]
  34. Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam. Eder, H.G., Stein, A., Fisher, R.S. Epilepsy Res. (1997) [Pubmed]
  35. Positron emission tomography in partial epilepsies: the clinical point of view. Koutroumanidis, M., Binnie, C.D., Panayiotopoulos, C.P. Nuclear medicine communications. (1998) [Pubmed]
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