- A missense mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male-limited precocious puberty. Kraaij, R., Post, M., Kremer, H., Milgrom, E., Epping, W., Brunner, H.G., Grootegoed, J.A., Themmen, A.P. J. Clin. Endocrinol. Metab. (1995)