Gene Review:
LHCGR - luteinizing hormone/choriogonadotropin...
Homo sapiens
Synonyms:
HHG, LCGR, LGR2, LH/CG-R, LH/CGR, ...
- A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies. Banerjee, S., Smallwood, A., Chambers, A.E., Papageorghiou, A., Loosfelt, H., Spencer, K., Campbell, S., Nicolaides, K. Reprod. Biol. Endocrinol. (2005)
- Expression of gonadotropin and activin receptor messenger ribonucleic acid in human ovarian epithelial neoplasms. Minegishi, T., Kameda, T., Hirakawa, T., Abe, K., Tano, M., Ibuki, Y. Clin. Cancer Res. (2000)
- Intracellular calcium mobilization in response to the activation of human wild-type and chimeric gonadotropin receptors. Lee, P.S., Buchan, A.M., Hsueh, A.J., Yuen, B.H., Leung, P.C. Endocrinology (2002)
- Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations. Chan, W.Y. Mol. Genet. Metab. (1998)
- Homozygous mutation within the conserved Ala-Phe-Asn-Glu-Thr motif of exon 7 of the LH receptor causes male pseudohermaphroditism. Gromoll, J., Schulz, A., Borta, H., Gudermann, T., Teerds, K.J., Greschniok, A., Nieschlag, E., Seif, F.J. Eur. J. Endocrinol. (2002)
- Spectral indices of cardiac autonomic function in obstructive sleep apnea. Khoo, M.C., Kim, T.S., Berry, R.B. Sleep. (1999)
- Brief report: testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene. Latronico, A.C., Anasti, J., Arnhold, I.J., Rapaport, R., Mendonca, B.B., Bloise, W., Castro, M., Tsigos, C., Chrousos, G.P. N. Engl. J. Med. (1996)
- Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Kremer, H., Kraaij, R., Toledo, S.P., Post, M., Fridman, J.B., Hayashida, C.Y., van Reen, M., Milgrom, E., Ropers, H.H., Mariman, E. Nat. Genet. (1995)
- Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Iiri, T., Herzmark, P., Nakamoto, J.M., van Dop, C., Bourne, H.R. Nature (1994)
- A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Shenker, A., Laue, L., Kosugi, S., Merendino, J.J., Minegishi, T., Cutler, G.B. Nature (1993)
- Gonadotrophin receptors. Clayton, R.N. Baillieres Clin. Endocrinol. Metab. (1996)
- Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. Kero, J., Poutanen, M., Zhang, F.P., Rahman, N., McNicol, A.M., Nilson, J.H., Keri, R.A., Huhtaniemi, I.T. J. Clin. Invest. (2000)
- A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients. Piersma, D., Berns, E.M., Verhoef-Post, M., Uitterlinden, A.G., Braakman, I., Pols, H.A., Themmen, A.P. J. Clin. Endocrinol. Metab. (2006)
- Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas. Saner-Amigh, K., Mayhew, B.A., Mantero, F., Schiavi, F., White, P.C., Rao, C.V., Rainey, W.E. J. Clin. Endocrinol. Metab. (2006)
- A missense mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male-limited precocious puberty. Kraaij, R., Post, M., Kremer, H., Milgrom, E., Epping, W., Brunner, H.G., Grootegoed, J.A., Themmen, A.P. J. Clin. Endocrinol. Metab. (1995)
- The follicle-stimulating hormone receptor and luteinizing hormone receptor genes are closely linked in sheep and deer. Montgomery, G.W., Tate, M.L., Henry, H.M., Penty, J.M., Rohan, R.M. J. Mol. Endocrinol. (1995)
- The differential effects of the gonadotropin receptors on aromatase expression in primary cultures of immature rat granulosa cells are highly dependent on the density of receptors expressed and the activation of the inositol phosphate cascade. Donadeu, F.X., Ascoli, M. Endocrinology (2005)
- Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. Zhang, Y., Dufau, M.L. J. Steroid Biochem. Mol. Biol. (2003)
- EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. Zhang, Y., Dufau, M.L. Mol. Endocrinol. (2001)
- Association of human follitropin (FSH) receptor with splicing variant of human lutropin/choriogonadotropin receptor negatively controls the expression of human FSH receptor. Yamashita, S., Nakamura, K., Omori, Y., Tsunekawa, K., Murakami, M., Minegishi, T. Mol. Endocrinol. (2005)
- The unique exon 10 of the human luteinizing hormone receptor is necessary for expression of the receptor protein at the plasma membrane in the human luteinizing hormone receptor, but deleterious when inserted into the human follicle-stimulating hormone receptor. Zhang, F.P., Kero, J., Huhtaniemi, I. Mol. Cell. Endocrinol. (1998)
- Gonadotrophin receptor expression on human granulosa cells of low and normal responders to FSH. Thiruppathi, P., Shatavi, S., Dias, J.A., Radwanska, E., Luborsky, J.L. Mol. Hum. Reprod. (2001)
- Opposite contribution of two ligand-selective determinants in the N-terminal hormone-binding exodomain of human gonadotropin receptors. Vischer, H.F., Granneman, J.C., Bogerd, J. Mol. Endocrinol. (2003)
- Effects of a Thyroid-Stimulating Human Monoclonal Autoantibody (M22) on Functional Activity of LH and FSH Receptors. Tonacchera, M., Ferrarini, E., Dimida, A., Agretti, P., Marco, G.D., Pinchera, A., Sanders, J., Evans, M., Richards, T., Furmaniak, J., Smith, B.R. Thyroid (2006)
- Functional importance of bovine myometrial and vascular LH receptors and cervical FSH receptors. Shemesh, M., Mizrachi, D., Gurevich, M., Stram, Y., Shore, L.S., Fields, M.J. Seminars in reproductive medicine. (2001)
- Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription. Zhang, Y., Fatima, N., Dufau, M.L. Mol. Cell. Biol. (2005)
- Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. Zhang, Y., Liao, M., Dufau, M.L. J. Biol. Chem. (2008)
- A functional transmembrane complex: The luteinizing hormone receptor with bound ligand and G protein. Puett, D., Li, Y., Demars, G., Angelova, K., Fanelli, F. Mol. Cell. Endocrinol. (2007)
- Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. Moore, S., Jaeschke, H., Kleinau, G., Neumann, S., Costanzi, S., Jiang, J.K., Childress, J., Raaka, B.M., Colson, A., Paschke, R., Krause, G., Thomas, C.J., Gershengorn, M.C. J. Med. Chem. (2006)
- Contribution of specific amino acid residues within the hFSH alpha 26-46 sequence region to FSH receptor-binding activity. Cattini-Schultz, S.V., Stanton, P.G., Robertson, D.M., Hearn, M.T. Pept. Res. (1995)
- GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. Hirakawa, T., Galet, C., Kishi, M., Ascoli, M. J. Biol. Chem. (2003)
- Transcriptional and posttranscriptional mechanisms in epidermal growth factor regulation of human chorionic gonadotropin (hCG) subunits and hCG receptor gene expression in human choriocarcinoma cells. Cao, H., Lei, Z.M., Rao, C.V. Endocrinology (1994)
- Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. Zhang, Y., Dufau, M.L. J. Biol. Chem. (2000)
- Immunohistochemical localization of the LH/HCG receptor in human ovary: HCG enhances cell surface expression of LH/HCG receptor on luteinizing granulosa cells in vitro. Takao, Y., Honda, T., Ueda, M., Hattori, N., Yamada, S., Maeda, M., Fujiwara, H., Mori, T., Wimalasena, J. Mol. Hum. Reprod. (1997)
- Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. Kremer, H., Mariman, E., Otten, B.J., Moll, G.W., Stoelinga, G.B., Wit, J.M., Jansen, M., Drop, S.L., Faas, B., Ropers, H.H. Hum. Mol. Genet. (1993)
- Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. Zhang, Y., Dufau, M.L. Mol. Cell. Biol. (2003)
- Specificity of cognate ligand-receptor interactions: fusion proteins of human chorionic gonadotropin and the heptahelical receptors for human luteinizing hormone, thyroid-stimulating hormone, and follicle-stimulating hormone. Schubert, R.L., Narayan, P., Puett, D. Endocrinology (2003)
- The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction. Davis, D.P., Rozell, T.G., Liu, X., Segaloff, D.L. Mol. Endocrinol. (1997)
- Cloning and functional characterization of a gonadal luteinizing hormone receptor complementary DNA from the African catfish (Clarias gariepinus). Vischer, H.F., Bogerd, J. Biol. Reprod. (2003)