A novel Leydig cell cDNA-derived protein is a relaxin-like factor.
According to Burkhardt et al. (Burkhardt, E., Adham, I. M., Brosig, B., Gastmann, A., Mattei, M. G., and Engel, W. (1994) Genomics 20, 13-19) Leydig cells contain the message for a protein of the insulin/ relaxin family which was named Leydig cell insulin-like protein (LEY I-L). We have synthesized the human LEY I-L according to the amino acid sequence deduced from the published cDNA structure and obtained preliminary results concerning its potential target organs and its biological activity. Leydig cell insulin-like protein binds specifically to crude membrane preparations of mouse uterus and brain and shows cross-reactivity with the relaxin receptor, but not the insulin receptor. On the basis of these observations, together with the results of earlier structure-function considerations, we suggest that the new protein is a relaxin-like factor. By itself the new factor shows no obvious effect, but when given together with relaxin it significantly enhances relaxin-mediated widening of the mouse symphysis pubis.[1]References
- A novel Leydig cell cDNA-derived protein is a relaxin-like factor. Büllesbach, E.E., Schwabe, C. J. Biol. Chem. (1995) [Pubmed]
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