Gene Review:
RXFP1 - relaxin/insulin-like family peptide...
Homo sapiens
Synonyms:
LGR7, Leucine-rich repeat-containing G-protein coupled receptor 7, RXFPR1, Relaxin family peptide receptor 1, Relaxin receptor 1
Silvertown,
Burazin,
Parry,
Samuel,
Bond,
Weber,
Summerlee,
Samuel,
Hewitson,
Layfield,
Amento,
Ma,
Summers,
Alexander I. Agoulnik,
Gillian D. Bryant-Greenwood,
Bond,
Tregear,
Zhao,
Schweickhardt,
Tregear,
Martini,
Dawson,
Summers,
Wade,
Reytomas,
Burazin,
Zhao,
Kelton,
Trojanowicz,
Gundlach,
Ryan,
Chevrier,
Layfield,
András Kern,
Daniela Hubbard,
Aaron Amano,
Gillian D. Bryant-Greenwood,
Hombach-Klonisch,
Ferraro,
Holzhausen,
Bathgate,
Hoang-Vu,
Dralle,
He,
Klonisch,
Claasz,
András Kern,
Bathgate,
Muda,
Shen,
Bialek,
Taylor,
- Relaxin Family Peptide Receptors - former orphans reunite with their parent ligands to activate multiple signalling pathways. Halls, M.L., van der Westhuizen, E.T., Bathgate, R.A., Summers, R.J. Br. J. Pharmacol. (2007)
- Genetic targeting of relaxin and insl3 signaling in mice. Feng, S., Bogatcheva, N.V., Kamat, A.A., Agoulnik, A.I. Ann. N. Y. Acad. Sci. (2005)
- The NMR Solution Structure of the Relaxin (RXFP1) Receptor Lipoprotein Receptor Class A Module and Identification of Key Residues in the N-terminal Region of the Module That Mediate Receptor Activation. Hopkins, E.J., Layfield, S., Ferraro, T., Bathgate, R.A., Gooley, P.R. J. Biol. Chem. (2007)
- Relaxin enhances the oncogenic potential of human thyroid carcinoma cells. Hombach-Klonisch, S., Bialek, J., Trojanowicz, B., Weber, E., Holzhausen, H.J., Silvertown, J.D., Summerlee, A.J., Dralle, H., Hoang-Vu, C., Klonisch, T. Am. J. Pathol. (2006)
- Characterization of Novel Splice Variants of LGR7 and LGR8 Reveals That Receptor Signaling Is Mediated by Their Unique Low Density Lipoprotein Class A Modules. Scott, D.J., Layfield, S., Yan, Y., Sudo, S., Hsueh, A.J., Tregear, G.W., Bathgate, R.A. J. Biol. Chem. (2006)
- Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism. Figueiredo, K.A., Mui, A.L., Nelson, C.C., Cox, M.E. J. Biol. Chem. (2006)
- Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes. Halls, M.L., Bathgate, R.A., Summers, R.J. J. Pharmacol. Exp. Ther. (2007)
- Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8). Halls, M.L., Bond, C.P., Sudo, S., Kumagai, J., Ferraro, T., Layfield, S., Bathgate, R.A., Summers, R.J. J. Pharmacol. Exp. Ther. (2005)
- Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity. Muda, M., He, C., Martini, P.G., Ferraro, T., Layfield, S., Taylor, D., Chevrier, C., Schweickhardt, R., Kelton, C., Ryan, P.L., Bathgate, R.A. Mol. Hum. Reprod. (2005)
- Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. Bond, C.P., Parry, L.J., Samuel, C.S., Gehring, H.M., Lederman, F.L., Rogers, P.A., Summers, R.J. J. Clin. Endocrinol. Metab. (2004)
- Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Bathgate, R.A., Lin, F., Hanson, N.F., Otvos, L., Guidolin, A., Giannakis, C., Bastiras, S., Layfield, S.L., Ferraro, T., Ma, S., Zhao, C., Gundlach, A.L., Samuel, C.S., Tregear, G.W., Wade, J.D. Biochemistry (2006)
- Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: restricted somatic co-expression a clue to relaxin action? Ma, S., Shen, P.J., Burazin, T.C., Tregear, G.W., Gundlach, A.L. Neuroscience (2006)
- Evidence for local relaxin ligand-receptor expression and function in arteries. Novak, J., Parry, L.J., Matthews, J.E., Kerchner, L.J., Indovina, K., Hanley-Yanez, K., Doty, K.D., Debrah, D.O., Shroff, S.G., Conrad, K.P. FASEB J. (2006)
- Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3',5'-monophosphate by relaxin. Nguyen, B.T., Yang, L., Sanborn, B.M., Dessauer, C.W. Mol. Endocrinol. (2003)
- The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Hsu, S.Y., Kudo, M., Chen, T., Nakabayashi, K., Bhalla, A., van der Spek, P.J., van Duin, M., Hsueh, A.J. Mol. Endocrinol. (2000)
- Demonstration of a relaxin receptor and relaxin-stimulated tyrosine phosphorylation in human lower uterine segment fibroblasts. Palejwala, S., Stein, D., Wojtczuk, A., Weiss, G., Goldsmith, L.T. Endocrinology (1998)
- The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Kern, A., Agoulnik, A.I., Bryant-Greenwood, G.D. Endocrinology (2007)
- Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes. Kern, A., Hubbard, D., Amano, A., Bryant-Greenwood, G.D. Endocrinology (2008)
- The receptor-binding site of human relaxin II. A dual prong-binding mechanism. Büllesbach, E.E., Yang, S., Schwabe, C. J. Biol. Chem. (1992)
- Receptors for relaxin family peptides. Bathgate, R.A., Ivell, R., Sanborn, B.M., Sherwood, O.D., Summers, R.J. Ann. N. Y. Acad. Sci. (2005)
- Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. Halls, M.L., Bathgate, R.A., Summers, R.J. Mol. Pharmacol. (2006)
- H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. Sudo, S., Kumagai, J., Nishi, S., Layfield, S., Ferraro, T., Bathgate, R.A., Hsueh, A.J. J. Biol. Chem. (2003)
- Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells. Tang, M., Mazella, J., Zhu, H.H., Tseng, L. Mol. Hum. Reprod. (2005)
- The Human Relaxin Receptor (LGR7): Expression in the Fetal Membranes and Placenta. Lowndes, K., Amano, A., Yamamoto, S.Y., Bryant-Greenwood, G.D. Placenta (2006)
- An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. Qin, X., Garibay-Tupas, J., Chua, P.K., Cachola, L., Bryant-Greenwood, G.D. Biol. Reprod. (1997)
- Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle. Luna, J.J., Riesewijk, A., Horcajadas, J.A., Van Os Rd, R., Domínguez, F., Mosselman, S., Pellicer, A., Simón, C. Mol. Hum. Reprod. (2004)
- Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. Bathgate, R.A., Samuel, C.S., Burazin, T.C., Layfield, S., Claasz, A.A., Reytomas, I.G., Dawson, N.F., Zhao, C., Bond, C., Summers, R.J., Parry, L.J., Wade, J.D., Tregear, G.W. J. Biol. Chem. (2002)
- Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Samuel, C.S., Zhao, C., Bond, C.P., Hewitson, T.D., Amento, E.P., Summers, R.J. Kidney Int. (2004)