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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus pneumoniae meningitis.

A young boy had meningitis caused by Streptococcus pneumoniae that was relatively resistant to penicillin and susceptible to cefotaxime. After 10 days of therapy with penicillin and cefotaxime, fever recurred and a second lumbar puncture revealed a pneumococcus that was resistant to all beta-lactam antibiotics. We now add vancomycin to empiric third-generation cephalosporin therapy for meningitis in children when gram-positive cocci are seen on the cerebrospinal fluid smear.[1]

References

  1. Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus pneumoniae meningitis. Muñoz, M., Valderrabanos, E.S., Diaz, E., Silva, J.J., Soult, J.A., Infante, P., Lopez, J.D., Garcia-Curiel, A. J. Pediatr. (1995) [Pubmed]
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