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MeSH Review

Spinal Puncture

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Disease relevance of Spinal Puncture


Psychiatry related information on Spinal Puncture


High impact information on Spinal Puncture


Chemical compound and disease context of Spinal Puncture


Biological context of Spinal Puncture


Anatomical context of Spinal Puncture

  • In CSF specimens obtained by serial lumbar punctures from patients with progressive MS who received five daily infusions of anti-T11, 70 +/- 12% of the T cells had mouse antibody bound to their surface by 72 to 96 hours [25].
  • Eight patients undergoing lumbar puncture for various neurologic disorders without inflamed meninges received a single dose of 10 mg/kg amdinocillin intravenously [26].
  • In a subset of subjects who underwent a lumbar puncture, there was a trend for the perimetry-abnl group to have a higher concentration of beta2 microglobulin, a marker for central nervous system immune activation [27].
  • IMPase activity was relatively constant in CSF obtained from repeated lumbar puncture and there was no significant rostro-caudal gradient of activity in either normal or DS subjects, indicating that the enzyme originates from both brain and spinal cord [28].
  • PATIENTS: Individuals from 1 to 18 yrs of age who had intravenous midazolam sedation and ketamine anesthesia administered while undergoing lumbar puncture, bone biopsy, central venous catheter placement, liver biopsy, thoracentesis, or bone marrow aspirate/biopsy [29].

Associations of Spinal Puncture with chemical compounds


Gene context of Spinal Puncture

  • Analysis of kinetic changes from serial lumbar punctures showed that these MMPs are independently regulated, and correlate only partly with CSF cytosis or levels of the endogenous inhibitor, tissue inhibitor of matrix metalloproteinase-1 [35].
  • We cross-sectionally analyzed the relationship of IL-1 beta and IL-1ra levels to leucocyte count in terms of interval between clinical onset and lumbar puncture [36].
  • Blood samples for hormonal measurements were obtained by venipuncture and in-parallel CSF samples for leptin/ghrelin determination were obtained by lumbar puncture [37].
  • This study was conducted to assess whether a low baseline level of CSF SRIF was associated with response to nimodipine treatment.METHODS: Twenty-one depressed patients underwent lumbar puncture for analysis of CSF somatostatin-like immunoreactivity (SRIF-LI) during a medication-free period and after at least 6 weeks of nimodipine monotherapy [38].
  • METHODS: 15 depressed patients (4 male, 11 female, 12 bipolar, and 3 unipolar) during a double-blind, medication-free period of at least 2 weeks duration, underwent a baseline lumbar puncture followed by a TRH stimulation test [39].

Analytical, diagnostic and therapeutic context of Spinal Puncture


  1. Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. Shapiro, W.R., Young, D.F., Mehta, B.M. N. Engl. J. Med. (1975) [Pubmed]
  2. 'Normal' CSF in bacterial meningitis. Onorato, I.M., Wormser, G.P., Nicholas, P. JAMA (1980) [Pubmed]
  3. Syncope of unknown origin. The need for a more cost-effective approach to its diagnosis evaluation. Kapoor, W.N., Karpf, M., Maher, Y., Miller, R.A., Levey, G.S. JAMA (1982) [Pubmed]
  4. Cerebrospinal fluid homovanillic acid and parkinsonism in Huntington's disease. Kurlan, R., Goldblatt, D., Zaczek, R., Jeffries, K., Irvine, C., Coyle, J., Shoulson, I. Ann. Neurol. (1988) [Pubmed]
  5. Lumbar puncture in asymptomatic late syphilis. An analysis of the benefits and risks. Wiesel, J., Rose, D.N., Silver, A.L., Sacks, H.S., Bernstein, R.H. Arch. Intern. Med. (1985) [Pubmed]
  6. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Virkkunen, M., Rawlings, R., Tokola, R., Poland, R.E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S.L., Linnoila, M. Arch. Gen. Psychiatry (1994) [Pubmed]
  7. Cortisol and Alzheimer's disease, I: Basal studies. Davis, K.L., Davis, B.M., Greenwald, B.S., Mohs, R.C., Mathé, A.A., Johns, C.A., Horvath, T.B. The American journal of psychiatry. (1986) [Pubmed]
  8. Changes in cerebrospinal fluid cyclic nucleotides in alcohol-dependent patients suffering from delirium tremens. Zimmer, R., Cramer, H., Athen, D., Beckmann, H. Biol. Psychiatry (1982) [Pubmed]
  9. The clinical effect of lumbar puncture in normal pressure hydrocephalus. Wikkelsø, C., Andersson, H., Blomstrand, C., Lindqvist, G. J. Neurol. Neurosurg. Psychiatr. (1982) [Pubmed]
  10. Gamma-hydroxybutyrate treatment of schizophrenia: a pilot study. Schulz, S.C., van Kammen, D.P., Buchsbaum, M.S., Roth, R.H., Alexander, P., Bunney, W.E. Pharmacopsychiatria. (1981) [Pubmed]
  11. JAMA patient page. Lumbar puncture. Torpy, J.M. JAMA (2002) [Pubmed]
  12. Primary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients. Quagliarello, V.J., Viscoli, C., Horwitz, R.I. Lancet (1995) [Pubmed]
  13. Lumbar puncture and febrile convulsions. Lorber, J., Sunderland, R. Lancet (1980) [Pubmed]
  14. Dysphoric mania. Clinical and biological correlates. Post, R.M., Rubinow, D.R., Uhde, T.W., Roy-Byrne, P.P., Linnoila, M., Rosoff, A., Cowdry, R. Arch. Gen. Psychiatry (1989) [Pubmed]
  15. Levels and disappearance of prostaglandin F2alpha in cerebral spinal fluid: a clinical and experimental study. Hagen, A.A., Gerber, J.N., Sweeley, C.C., White, R.P., Robertson, J.T. Stroke (1977) [Pubmed]
  16. Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache. Bailey, D.M., Roukens, R., Knauth, M., Kallenberg, K., Christ, S., Mohr, A., Genius, J., Storch-Hagenlocher, B., Meisel, F., McEneny, J., Young, I.S., Steiner, T., Hess, K., Bärtsch, P. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  17. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features. Marra, C.M., Maxwell, C.L., Smith, S.L., Lukehart, S.A., Rompalo, A.M., Eaton, M., Stoner, B.P., Augenbraun, M., Barker, D.E., Corbett, J.J., Zajackowski, M., Raines, C., Nerad, J., Kee, R., Barnett, S.H. J. Infect. Dis. (2004) [Pubmed]
  18. Hydrocephalus in tuberculous meningitis in children: treatment with acetazolamide and repeated lumbar puncture. Visudhiphan, P., Chiemchanya, S. J. Pediatr. (1979) [Pubmed]
  19. Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus pneumoniae meningitis. Muñoz, M., Valderrabanos, E.S., Diaz, E., Silva, J.J., Soult, J.A., Infante, P., Lopez, J.D., Garcia-Curiel, A. J. Pediatr. (1995) [Pubmed]
  20. Cryptococcal meningitis in a child with hyperimmunoglobulin E syndrome. Garty, B.Z., Wolach, B., Ashkenazi, S., Weismart, Y., Rachmel, A., Nitzan, M. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (1995) [Pubmed]
  21. Single injection treatment of meningococcal meningitis. 2. Long-acting chloramphenicol. Wali, S.S., Macfarlane, J.T., Weir, W.R., Cleland, P.G., Ball, P.A., Hassan-King, M., Whittle, H.C., Greenwood, B.M. Trans. R. Soc. Trop. Med. Hyg. (1979) [Pubmed]
  22. Cerebrospinal fluid lactate dehydrogenase in infants with perinatal asphyxia. Hall, R.T., Kulkarni, P.B., Sheehan, M.B., Rhodes, P.G. Developmental medicine and child neurology. (1980) [Pubmed]
  23. Central nervous system metastases in neuroblastoma: radiologic, clinical, and biologic features in 23 patients. Matthay, K.K., Brisse, H., Couanet, D., Couturier, J., Bénard, J., Mosseri, V., Edeline, V., Lumbroso, J., Valteau-Couanet, D., Michon, J. Cancer (2003) [Pubmed]
  24. Competence of new emergency medicine residents in the performance of lumbar punctures. Lammers, R.L., Temple, K.J., Wagner, M.J., Ray, D. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (2005) [Pubmed]
  25. In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis. Hafler, D.A., Weiner, H.L. Ann. Neurol. (1987) [Pubmed]
  26. Amdinocillin pharmacokinetics. Simultaneous administration with cephalothin and cerebrospinal fluid penetration. Gambertoglio, J.G., Barriere, S.L., Lin, E.T., Conte, J.E. Am. J. Med. (1983) [Pubmed]
  27. Neuropsychological impairment-associated visual field deficits in HIV infection. HNRC Group. HIV Neurobehavioral Research Center. Plummer, D.J., Marcotte, T.D., Sample, P.A., Wolfson, T., Heaton, R.K., Grant, I., Freeman, W.R. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  28. Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF. Atack, J.R., Schapiro, M.B. Neurobiol. Aging (2002) [Pubmed]
  29. Sedation for pediatric procedures, using ketamine and midazolam, in a primarily adult intensive care unit: a retrospective evaluation. Slonim, A.D., Ognibene, F.P. Crit. Care Med. (1998) [Pubmed]
  30. Cerebrospinal fluid monoamine metabolite levels in male arsonists. Virkkunen, M., Nuutila, A., Goodwin, F.K., Linnoila, M. Arch. Gen. Psychiatry (1987) [Pubmed]
  31. Monoamine metabolites in CSF and suicidal behavior. Träskman, L., Asberg, M., Bertilsson, L., Sjöstrand, L. Arch. Gen. Psychiatry (1981) [Pubmed]
  32. Pseudotumor cerebri. Ahlskog, J.E., O'Neill, B.P. Ann. Intern. Med. (1982) [Pubmed]
  33. The lumbar puncture for diagnosis of pediatric neurotransmitter diseases. Hyland, K. Ann. Neurol. (2003) [Pubmed]
  34. Stability of monoamine metabolites in human cerebrospinal fluid. Langlais, P.J., Bird, E.D., McEntee, W.J. Ann. Neurol. (1982) [Pubmed]
  35. Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children. Lindberg, R.L., Sorsa, T., Tervahartiala, T., Hoffmann, F., Mellanen, L., Kappos, L., Schaad, U.B., Leib, S.L., Leppert, D. Neuropathol. Appl. Neurobiol. (2006) [Pubmed]
  36. Interleukin-1 beta and interleukin-1 receptor antagonist levels in cerebrospinal fluid of aseptic meningitis patients. Yokoyama, T., Oda, M., Seino, Y. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (1998) [Pubmed]
  37. Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's disease. Popovic, V., Svetel, M., Djurovic, M., Petrovic, S., Doknic, M., Pekic, S., Miljic, D., Milic, N., Glodic, J., Dieguez, C., Casanueva, F.F., Kostic, V. Eur. J. Endocrinol. (2004) [Pubmed]
  38. Low CSF somatostatin associated with response to nimodipine in patents with affective illness. Frye, M.A., Pazzaglia, P.J., George, M.S., Luckenbaugh, D.A., Vanderham, E., Davis, C.L., Rubinow, D.R., Post, R.M. Biol. Psychiatry (2003) [Pubmed]
  39. Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression. Frye, M.A., Dunn, R.T., Gary, K.A., Kimbrell, T.A., Callahan, A.M., Luckenbaugh, D.A., Corá-Locatelli, G., Vanderham, E., Winokur, A., Post, R.M. Biol. Psychiatry (1999) [Pubmed]
  40. Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects: negative findings. Roy, A., Wolkowitz, O.M., Bissette, G., Nemeroff, C.B. The American journal of psychiatry. (1994) [Pubmed]
  41. Clinical outcome in pneumococcal meningitis correlates with CSF lipoteichoic acid concentrations. Schneider, O., Michel, U., Zysk, G., Dubuis, O., Nau, R. Neurology (1999) [Pubmed]
  42. Outpatient lumbar myelography. Initial results in 79 examinations using a low-dose metrizamide technique. Tate, C.F., Wilkov, H.R., Lestrange, N.R., Gardiner, H.F., Stein, K.R. Radiology. (1985) [Pubmed]
  43. Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Martin, W.J., Gupta, N.K., Loo, C.M., Rohde, D.S., Basbaum, A.I. Pain (1999) [Pubmed]
  44. Monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Davidson, D., Pullar, I.A., Mawdsley, C., Kinloch, N., Yates, C.M. J. Neurol. Neurosurg. Psychiatr. (1977) [Pubmed]
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