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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Secretion and processing mechanisms of procathepsin L in bone resorption.

Secretion of procathepsin L into the culture medium from a bone cell mixture was markedly enhanced by addition of parathyroid hormone (PTH), 1 alpha,25-(OH)2D3 or tumor necrosis factor alpha (TNF alpha). These stimulators of secretion of procathepsin L enhanced bone pit formation, which was inhibited by E-64, but not by CA-074, a specific inhibitor of cathepsin B. Procathepsin L may thus participate in the process of bone collagenolysis during bone resorption. Procathepsin L partially purified from rat long bones under cold conditions was rapidly converted to the mature form under acidic conditions at room temperature. This conversion was inhibited by E-64, suggesting that the procathepsin L secreted into lacunae is catalytically converted to the mature enzyme by cysteine proteinase(s).[1]


  1. Secretion and processing mechanisms of procathepsin L in bone resorption. Kakegawa, H., Tagami, K., Ohba, Y., Sumitani, K., Kawata, T., Katunuma, N. FEBS Lett. (1995) [Pubmed]
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