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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Rab and rho GTPases are involved in specific response of periodontal ligament fibroblasts to mechanical stretching.

To investigate the contribution of ras-related signalling molecules to the mechanotransduction process, stretch-sensing human periodontal ligament (PDL) fibroblasts were isolated and cultured in dishes with a flexible bottom. The cells were stimulated by stretching the bottom of the dishes and membrane fractions were prepared and analysed at the level of mapping small GTP-binding proteins by high resolution two-dimensional gel electrophoresis followed by renaturing transfer and an [alpha-32P]GTP-overlay procedure. This analysis revealed that mechanically-stretched PDL fibroblasts exhibit complete down-regulation of rhoA and induction of rab6, rab17 and a putative member of the rab3 subfamily in a cell type-specific manner.[1]

References

  1. Rab and rho GTPases are involved in specific response of periodontal ligament fibroblasts to mechanical stretching. Basdra, E.K., Papavassiliou, A.G., Huber, L.A. Biochim. Biophys. Acta (1995) [Pubmed]
 
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