Disease relevance of RAB17

• The rab17 gene from maize is transcribed in late embryonic development and is responsive to abscisic acid and water stress in embryo and vegetative tissues [1].

High impact information on RAB17

• By confocal immunofluorescence microscopy, rab17 colocalized with internalized transferrin in the perinuclear recycling endosome of BHK-21 cells [2].
• Basolateral to apical transport of two membrane-bound markers, the transferrin receptor and the FcLR 5-27 chimeric receptor, was specifically increased in Eph4 cells expressing rab17 mutants defective in either GTP binding or hydrolysis [2].
• Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells [2].
• In polarized Eph4 cells, rab17 associated with the apical recycling endosome that has been implicated in recycling and transcytosis [2].
• By immunofluorescence and immunoelectron microscopy on kidney sections, rab17 was localized to the basolateral plasma membrane and to apical tubules [3].

Chemical compound and disease context of RAB17

• Response of Lathyrus sativus plants to water stress showed that ABA responsive genes such as PLE 25, TAS 14 and RAB 17 are synthesized constitutively, the levels of which decline gradually with increase in water stress or ABA levels [4].

Biological context of RAB17

• There were differences in protein binding and function of the five ABREs in the rab17 promoter [1].
• In the present study, we isolated dehydrin DHN1, also known as Rab17 protein, from maize kernel by an acid extraction method, removed the phosphoric acid groups from phosphorylated residues by beta-elimination via treating the protein with barium hydroxide, and identified the sites of phosphorylation by tandem mass spectrometry [5].
• This analysis revealed that mechanically-stretched PDL fibroblasts exhibit complete down-regulation of rhoA and induction of rab6, rab17 and a putative member of the rab3 subfamily in a cell type-specific manner [6].

Anatomical context of RAB17

• To determine whether rab17 is specific for epithelial cells we studied its expression in the developing kidney [3].

Associations of RAB17 with chemical compounds

• The cis-acting sequences can be divided in embryo-specific, ABA-specific and leaf-specific elements on the basis of protein binding and the ability to confer expression of rab17 [1].
• Regulatory elements in vivo in the promoter of the abscisic acid responsive gene rab17 from maize [1].

Other interactions of RAB17

• In this study, phylogenetic analysis of 5'-noncoding sequences was optimized using rab17, a well-characterized ABA-responsive gene from maize, and five additional rab16/17 homologs from sorghum and rice [7].

Analytical, diagnostic and therapeutic context of RAB17

• In situ hybridization studies on the embryonic kidney and intestine revealed that rab17 is restricted to epithelial cells [3].
• Northern blot analysis on various mouse organs, revealed that the rab17 mRNA is present in kidney, liver, and intestine but not in organs lacking epithelial cells nor in fibroblasts [3].

References