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Gene Review

RAB17  -  RAB17, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-17
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Disease relevance of RAB17


High impact information on RAB17


Chemical compound and disease context of RAB17

  • Response of Lathyrus sativus plants to water stress showed that ABA responsive genes such as PLE 25, TAS 14 and RAB 17 are synthesized constitutively, the levels of which decline gradually with increase in water stress or ABA levels [4].

Biological context of RAB17

  • There were differences in protein binding and function of the five ABREs in the rab17 promoter [1].
  • In the present study, we isolated dehydrin DHN1, also known as Rab17 protein, from maize kernel by an acid extraction method, removed the phosphoric acid groups from phosphorylated residues by beta-elimination via treating the protein with barium hydroxide, and identified the sites of phosphorylation by tandem mass spectrometry [5].
  • This analysis revealed that mechanically-stretched PDL fibroblasts exhibit complete down-regulation of rhoA and induction of rab6, rab17 and a putative member of the rab3 subfamily in a cell type-specific manner [6].

Anatomical context of RAB17


Associations of RAB17 with chemical compounds

  • The cis-acting sequences can be divided in embryo-specific, ABA-specific and leaf-specific elements on the basis of protein binding and the ability to confer expression of rab17 [1].
  • Regulatory elements in vivo in the promoter of the abscisic acid responsive gene rab17 from maize [1].

Other interactions of RAB17

  • In this study, phylogenetic analysis of 5'-noncoding sequences was optimized using rab17, a well-characterized ABA-responsive gene from maize, and five additional rab16/17 homologs from sorghum and rice [7].

Analytical, diagnostic and therapeutic context of RAB17


  1. Regulatory elements in vivo in the promoter of the abscisic acid responsive gene rab17 from maize. Busk, P.K., Jensen, A.B., Pagès, M. Plant J. (1997) [Pubmed]
  2. Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. Zacchi, P., Stenmark, H., Parton, R.G., Orioli, D., Lim, F., Giner, A., Mellman, I., Zerial, M., Murphy, C. J. Cell Biol. (1998) [Pubmed]
  3. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. Lütcke, A., Jansson, S., Parton, R.G., Chavrier, P., Valencia, A., Huber, L.A., Lehtonen, E., Zerial, M. J. Cell Biol. (1993) [Pubmed]
  4. Effect of water stress on proline content and transcript levels in Lathyrus sativus. Tyagi, A., Santha, I.M., Mehta, S.L. Indian J. Biochem. Biophys. (1999) [Pubmed]
  5. Beta-elimination coupled with tandem mass spectrometry for the identification of in vivo and in vitro phosphorylation sites in maize dehydrin DHN1 protein. Jiang, X., Wang, Y. Biochemistry (2004) [Pubmed]
  6. Rab and rho GTPases are involved in specific response of periodontal ligament fibroblasts to mechanical stretching. Basdra, E.K., Papavassiliou, A.G., Huber, L.A. Biochim. Biophys. Acta (1995) [Pubmed]
  7. Phylogenetic analysis of 5'-noncoding regions from the ABA-responsive rab16/17 gene family of sorghum, maize and rice provides insight into the composition, organization and function of cis-regulatory modules. Buchanan, C.D., Klein, P.E., Mullet, J.E. Genetics (2004) [Pubmed]
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