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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Amenorrhea and edema.

In a 22 year old woman extensive edema developed during evaluation for amenorrhea. It was learned then that she was consuming escessive amounts of a laxative daily. Balance studies were performed which demonstrated that she excreted large amounts of sodium in her liquid stools while taking the dose of laxative she had been using. The presence of increased plasma renin activity and increased urinary aldosterone suggest that in this patient the occurrence of the edema after she discontinued use of the laxative was due to secondary aldosteronism presumably caused by plasma volume depletion.[1]


  1. Amenorrhea and edema. Ullrich, I., Lizarralde, G. Am. J. Med. (1978) [Pubmed]
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