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Disease relevance of Hyperaldosteronism


High impact information on Hyperaldosteronism


Chemical compound and disease context of Hyperaldosteronism

  • Captopril prevented and reversed the secondary hyperaldosteronism and hypokalaemia induced by simultaneous diuretic administration, thus eliminating the need for potassium supplements [9].
  • In patients with primary hyperaldosteronism adrenal-vein plasma aldosterone/cortisol concentration ratios successfully lateralised all 21 adenomas [10].
  • The absorptive mechanisms of K+ are not disturbed by diarrhea per se, but fecal K+ losses are increased in diarrheal diseases by unabsorbed anions (which obligate K+), by electrochemical gradients secondary to active chloride secretion, and probably by secondary hyperaldosteronism [11].
  • Metoclopramide and secondary hyperaldosteronism [12].
  • We have compared four localizing techniques--adrenal venography, adrenal isotopic scanning, a modified adrenal venous sampling for steroid measurements, and the anomalous postural decrease in plasma aldosterone concentration--in 51 patients with primary aldosteronism, all of whom had undergone operative confirmation [13].
  • Genetic studies excluded mutation at the aldosterone synthase locus, further distinguishing this disorder from glucocorticoid-remediable aldosteronism [14].

Biological context of Hyperaldosteronism


Anatomical context of Hyperaldosteronism


Gene context of Hyperaldosteronism


Analytical, diagnostic and therapeutic context of Hyperaldosteronism


  1. Idiopathic hyperaldosteronism. A possible role for aldosterone-stimulating factor. Carey, R.M., Sen, S., Dolan, L.M., Malchoff, C.D., Bumpus, F.M. N. Engl. J. Med. (1984) [Pubmed]
  2. Use of computed tomography in diagnosing the cause of primary aldosteronism. White, E.A., Schambelan, M., Rost, C.R., Biglieri, E.G., Moss, A.A., Korobkin, M. N. Engl. J. Med. (1980) [Pubmed]
  3. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Lifton, R.P., Dluhy, R.G., Powers, M., Rich, G.M., Cook, S., Ulick, S., Lalouel, J.M. Nature (1992) [Pubmed]
  4. Surreptitious habitual vomiting simulating Bartter's syndrome. Ramos, E., Hall-Craggs, M., Demers, L.M. JAMA (1980) [Pubmed]
  5. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. Okubo, S., Niimura, F., Nishimura, H., Takemoto, F., Fogo, A., Matsusaka, T., Ichikawa, I. J. Clin. Invest. (1997) [Pubmed]
  6. Hazards of long-term dexamethasone treatment in primary aldosteronism. Hoefnagels, W.H., Kloppenborg, P.W. N. Engl. J. Med. (1982) [Pubmed]
  7. Disorders of steroid 11 beta-hydroxylase isozymes. White, P.C., Curnow, K.M., Pascoe, L. Endocr. Rev. (1994) [Pubmed]
  8. Landmark perspective: Renin in aldosteronism. Relating kidney and adrenal. Dustan, H.P. JAMA (1985) [Pubmed]
  9. Long-term effects of captopril (SQ14 225) on blood-pressure and hormone levels in essential hypertension. Johnston, C.I., Millar, J.A., McGrath, B.P., Matthews, P.G. Lancet (1979) [Pubmed]
  10. The diagnosis of primary hyperaldosteronism. Vaughan, N.J., Jowett, T.P., Slater, J.D., Wiggins, R.C., Lightman, S.L., Ma, J.T., Payne, N.N. Lancet (1981) [Pubmed]
  11. Pathophysiology of potassium absorption and secretion by the human intestine. Agarwal, R., Afzalpurkar, R., Fordtran, J.S. Gastroenterology (1994) [Pubmed]
  12. Metoclopramide and secondary hyperaldosteronism. Mazzacca, G., D'Arienzo, A., Ambrogio, G. Ann. Intern. Med. (1983) [Pubmed]
  13. Primary aldosteronism: diagnosis, localization, and treatment. Weinberger, M.H., Grim, C.E., Hollifield, J.W., Kem, D.C., Ganguly, A., Kramer, N.J., Yune, H.Y., Wellman, H., Donohue, J.P. Ann. Intern. Med. (1979) [Pubmed]
  14. A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism. Geller, D.S., Zhang, J., Wisgerhof, M.V., Shackleton, C., Kashgarian, M., Lifton, R.P. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  15. Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree. Pascoe, L., Jeunemaitre, X., Lebrethon, M.C., Curnow, K.M., Gomez-Sanchez, C.E., Gasc, J.M., Saez, J.M., Corvol, P. J. Clin. Invest. (1995) [Pubmed]
  16. Diagnosis and treatment of primary hyperaldosteronism. Blumenfeld, J.D., Sealey, J.E., Schlussel, Y., Vaughan, E.D., Sos, T.A., Atlas, S.A., Müller, F.B., Acevedo, R., Ulick, S., Laragh, J.H. Ann. Intern. Med. (1994) [Pubmed]
  17. A randomized comparison of metoclopramide and domperidone on plasma aldosterone concentration and on spironolactone-induced diuresis in ascitic cirrhotic patients. D'Arienzo, A., Ambrogio, G., Di Siervi, P., Perna, E., Squame, G., Mazzacca, G. Hepatology (1985) [Pubmed]
  18. Plasma renin activity and blood volume in uncontrolled diabetes. Ketoacidosis, a state of secondary aldosteronism. Christlieb, A.R., Assal, J.P., Katsilambros, N., Williams, G.H., Kozak, G.P., Suzuki, T. Diabetes (1975) [Pubmed]
  19. Amenorrhea and edema. Ullrich, I., Lizarralde, G. Am. J. Med. (1978) [Pubmed]
  20. Hypothyroidism affects the expression of electrogenic amiloride-sensitive sodium transport in rat colon. Pácha, J., Pohlová, I., Zemanová, Z. Gastroenterology (1996) [Pubmed]
  21. Increased adrenal medullary atrial natriuretic polypeptide synthesis in patients with primary aldosteronism. Lee, Y.J., Lin, S.R., Shin, S.J., Tsai, J.H. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  22. Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects. Hanukoglu, A. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  23. Aldosterone receptors in different types of primary hyperaldosteronism. Armanini, D., Witzgall, H., Wehling, M., Kuhnle, U., Weber, P.C. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  24. Renin-aldosterone response to dexamethasone in glucocorticoid-suppressible hyperaldosteronism is altered by coexistent renal artery stenosis. Stowasser, M., Gordon, R.D., Klemm, S.A., Tunny, T.J. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  25. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. Pascoe, L., Curnow, K.M., Slutsker, L., Connell, J.M., Speiser, P.W., New, M.I., White, P.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  26. Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism. Takeda, Y., Furukawa, K., Inaba, S., Miyamori, I., Mabuchi, H. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  27. Pituitary peptides other than ACTH may not be aldosterone secretagogue in primary aldosteronism. Miyamori, I., Koshida, H., Matsubara, T., Soma, R., Takasaki, H., Okamoto, S., Takeda, R. Exp. Clin. Endocrinol. (1990) [Pubmed]
  28. Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome. Arrighi, I., Bloch-Faure, M., Grahammer, F., Bleich, M., Warth, R., Mengual, R., Drici, M.D., Barhanin, J., Meneton, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Plasma atrial natriuretic peptide in primary aldosteronism (before and after treatment) and in Bartter's and Gordon's syndromes. Tunny, T.J., Gordon, R.D. Lancet (1986) [Pubmed]
  30. Role of dietary potassium in the hyperaldosteronism and hypertension of the remnant kidney model. Ibrahim, H.N., Hostetter, T.H. J. Am. Soc. Nephrol. (2000) [Pubmed]
  31. Myocardial scintigraphic characteristics in patients with primary aldosteronism. Abe, M., Hamada, M., Matsuoka, H., Shigematsu, Y., Sumimoto, T., Hiwada, K. Hypertension (1994) [Pubmed]
  32. Single dose captopril as a diagnostic test for primary aldosteronism. Lyons, D.F., Kem, D.C., Brown, R.D., Hanson, C.S., Carollo, M.L. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  33. Changes in left ventricular anatomy and function in hypertension and primary aldosteronism. Rossi, G.P., Sacchetto, A., Visentin, P., Canali, C., Graniero, G.R., Palatini, P., Pessina, A.C. Hypertension (1996) [Pubmed]
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