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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of ammonium chloride on multiplication of rinderpest virus in Vero cells.

Ammonium chloride, a lysosomotropic weak base, inhibited replication of rinderpest virus in Vero cells. The inhibition of replication was dose-dependent and the minimum effective dose of ammonium chloride was determined as 5-10 mmol/l. The fusion efficiency and the yield of both cell-free and cell-associated virus were reduced in the presence of the inhibitor. Western blot analysis of rinderpest virus-infected Vero cells revealed that synthesis of two virus-induced polypeptides were affected by the presence of ammonium chloride.[1]

References

  1. Effect of ammonium chloride on multiplication of rinderpest virus in Vero cells. Hemadri, D., Bandyopadhyay, S.K. Acta Virol. (1994) [Pubmed]
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