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Disease relevance of Rinderpest


High impact information on Rinderpest

  • Phosphoprotein of the rinderpest virus forms a tetramer through a coiled coil region important for biological function. A structural insight [6].
  • We report here the characterization of oligomeric P protein of rinderpest virus (RPV) and provide a structural basis for its multimerization [6].
  • We previously demonstrated that the rinderpest virus (RPV) hemagglutinin (H) protein plays an important role in determining host range but that other viral proteins are clearly required for full RPV pathogenicity to be manifest in different species [7].
  • In this study we show that CD46 is also downregulated to the same extent by wild-type, vaccine, and laboratory-passaged strains of rinderpest virus (RPV), although CD46 did not appear to be the receptor for RPV [8].
  • Administration of acetylsalicylic acid or mefenamic acid during experimental infection of rabbits with a rabbit-adapted strain of rinderpest virus did not prevent initiation of the febrile response but significantly reduced the duration of fever [9].

Chemical compound and disease context of Rinderpest

  • An indirect ELISA was used successfully to evaluate the status of cattle following the Pan African Rinderpest Campaign [10].
  • Preparation and characterization of monoclonal antibodies to nucleocapsid protein N and H glycoprotein of rinderpest virus [11].
  • Inhibition of replication of rinderpest virus by 5-fluorouracil [12].
  • Three new potential sequence motifs with homology to the alpha-subunit of the polymerase-associated nucleocapsid phosphoprotein of rinderpest virus, the Bowman-Birk type of proteinase inhibitors, and the metallothionein superfamily of cysteine rich chelating proteins have been identified [13].
  • Immunohistological localisation of rinderpest virus in formalin-fixed, paraffin-embedded tissues from experimentally infected cattle [14].

Biological context of Rinderpest


Anatomical context of Rinderpest


Gene context of Rinderpest


Analytical, diagnostic and therapeutic context of Rinderpest


  1. Long-term sterilizing immunity to rinderpest in cattle vaccinated with a recombinant vaccinia virus expressing high levels of the fusion and hemagglutinin glycoproteins. Verardi, P.H., Aziz, F.H., Ahmad, S., Jones, L.A., Beyene, B., Ngotho, R.N., Wamwayi, H.M., Yesus, M.G., Egziabher, B.G., Yilma, T.D. J. Virol. (2002) [Pubmed]
  2. Mapping of B-cell epitopes of hemagglutinin protein of rinderpest virus. Renukaradhya, G.J., Mitra-Kaushik, S., Sinnathamby, G., Rajasekhar, M., Shaila, M.S. Virology (2002) [Pubmed]
  3. Cloning and sequence analysis of the matrix (M) protein gene of rinderpest virus and evidence for another bovine morbillivirus. Baron, M.D., Goatley, L., Barrett, T. Virology (1994) [Pubmed]
  4. Analysis of the polypeptides synthesized in rinderpest virus-infected cells. Grubman, M.J., Mebus, C., Dale, B., Yamanaka, M., Yilma, T. Virology (1988) [Pubmed]
  5. Sequence analysis and editing of the phosphoprotein (P) gene of rinderpest virus. Yamanaka, M., Dale, B., Crisp, T., Cordell, B., Grubman, M., Yilma, T. Virology (1992) [Pubmed]
  6. Phosphoprotein of the rinderpest virus forms a tetramer through a coiled coil region important for biological function. A structural insight. Rahaman, A., Srinivasan, N., Shamala, N., Shaila, M.S. J. Biol. Chem. (2004) [Pubmed]
  7. Rinderpest virus phosphoprotein gene is a major determinant of species-specific pathogenicity. Yoneda, M., Miura, R., Barrett, T., Tsukiyama-Kohara, K., Kai, C. J. Virol. (2004) [Pubmed]
  8. Morbillivirus downregulation of CD46. Galbraith, S.E., Tiwari, A., Baron, M.D., Lund, B.T., Barrett, T., Cosby, S.L. J. Virol. (1998) [Pubmed]
  9. Effects of antipyretics in rinderpest virus infection in rabbits. Kurosawa, S., Kobune, F., Okuyama, K., Sugiura, A. J. Infect. Dis. (1987) [Pubmed]
  10. Recent developments in the diagnosis of rinderpest and peste des petits ruminants. Diallo, A., Libeau, G., Couacy-Hymann, E., Barbron, M. Vet. Microbiol. (1995) [Pubmed]
  11. Preparation and characterization of monoclonal antibodies to nucleocapsid protein N and H glycoprotein of rinderpest virus. Bhavani, K., Karande, A.A., Shaila, M.S. Virus Res. (1989) [Pubmed]
  12. Inhibition of replication of rinderpest virus by 5-fluorouracil. Ghosh, A., Nayak, R., Shaila, M.S. Antiviral Res. (1996) [Pubmed]
  13. Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster. Penzes, Z., Gonzalez, J.M., Calvo, E., Izeta, A., Smerdou, C., Méndez, A., Sanchez, C.M., Sola, I., Almazan, F., Enjuanes, L. Virus Genes (2001) [Pubmed]
  14. Immunohistological localisation of rinderpest virus in formalin-fixed, paraffin-embedded tissues from experimentally infected cattle. Gathumbi, P., Jönsson, L., Nilsson, C., Wamwayi, H., Wafula, J.S. Zentralblatt Veterinarmedizin Reihe B (1989) [Pubmed]
  15. Nucleotide sequence of cDNA to the rinderpest virus mRNA encoding the nucleocapsid protein. Kamata, H., Tsukiyama, K., Sugiyama, M., Kamata, Y., Yoshikawa, Y., Yamanouchi, K. Virus Genes (1991) [Pubmed]
  16. Booster immunization of antigen primed mice with anti-idiotypic T cells generates antigen-specific memory T cell response. Lal, G., Shaila, M.S., Nayak, R. Vaccine (2006) [Pubmed]
  17. Effect of ammonium chloride on multiplication of rinderpest virus in Vero cells. Hemadri, D., Bandyopadhyay, S.K. Acta Virol. (1994) [Pubmed]
  18. Domains of Rinderpest virus phosphoprotein involved in interaction with itself and the nucleocapsid protein. Shaji, D., Shaila, M.S. Virology (1999) [Pubmed]
  19. Sequencing and analysis of the nucleocapsid (N) and polymerase (L) genes and the terminal extragenic domains of the vaccine strain of rinderpest virus. Baron, M.D., Barrett, T. J. Gen. Virol. (1995) [Pubmed]
  20. Antigenic and functional characterization of rinderpest virus envelope proteins using monoclonal antibodies. Sugiyama, M., Minamoto, N., Kinjo, T., Hirayama, N., Asano, K., Tsukiyama-Kohara, K., Yoshikawa, Y., Yamanouchi, K. J. Gen. Virol. (1991) [Pubmed]
  21. Structural analysis of the human respiratory syncytial virus phosphoprotein: characterization of an alpha-helical domain involved in oligomerization. Llorente, M.T., García-Barreno, B., Calero, M., Camafeita, E., López, J.A., Longhi, S., Ferrón, F., Varela, P.F., Melero, J.A. J. Gen. Virol. (2006) [Pubmed]
  22. Competitive enzyme-linked immunosorbent assay based on monoclonal antibody and recombinant hemagglutinin for serosurveillance of rinderpest virus. Renukaradhya, G.J., Suresh, K.B., Rajasekhar, M., Shaila, M.S. J. Clin. Microbiol. (2003) [Pubmed]
  23. Cloning and expression of the nucleocapsid gene of virulent Kabete O strain of rinderpest virus in baculovirus: use in differential diagnosis between vaccinated and infected animals. Ismail, T., Ahmad, S., D'Souza-Ault, M., Bassiri, M., Saliki, J., Mebus, C., Yilma, T. Virology (1994) [Pubmed]
  24. Molecular cloning and sequence analysis of the rinderpest virus mRNA encoding the hemagglutinin protein. Tsukiyama, K., Sugiyama, M., Yoshikawa, Y., Yamanouchi, K. Virology (1987) [Pubmed]
  25. Simple and rapid dot-enzyme immunoassay for visual detection of rinderpest antibodies in bovine and caprine sera. Afshar, A., Myers, D.J. Tropical animal health and production. (1986) [Pubmed]
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