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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Specific assay method for the activities of cathepsin L-type cysteine proteinases.

We have established a new differential assay method for cathepsin L-type proteinases using specific inhibitors, E-64 for all cysteine proteinases, CA-074 for cathepsin B, and PLCPI for cathepsin L-type proteinases with Z-Phe-Arg-MCA as the substrate. The value of cathepsin B calculated by this method did not coincide with value assayed directly in terms of the hydrolysis of Z-Arg-Arg-MCA, a specific substrate for cathepsin B. The activities of cathepsin L-type proteinases, cathepsins B and J in rat liver and kidney were assayed at the same time using this new assay method as a representative example.[1]


  1. Specific assay method for the activities of cathepsin L-type cysteine proteinases. Inubushi, T., Kakegawa, H., Kishino, Y., Katunuma, N. J. Biochem. (1994) [Pubmed]
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