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Gene Review

Ctsb  -  cathepsin B

Rattus norvegicus

Synonyms: Cathepsin B, Cathepsin B1, RSG-2
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Disease relevance of Ctsb


High impact information on Ctsb

  • Mucosal presence and activity of cysteine PI and cathepsin B have also been investigated in the pathogenesis of chemically induced HML [5].
  • We extracted and partially isolated acid and thermostable inhibitors of cathepsin B in the gastric mucosa, and found rapid inactivation of PI and activation of cathepsin B in the early phase of E- or A-induced HML [5].
  • Ubiquitin mRNA in muscle returned to control levels within 24 h after cessation of acidosis. mRNA for subunits of the proteasome (C2 and C3) in muscle were also increased 4-fold and 2.5-fold, respectively, with acidosis; mRNA for cathepsin B did not change [6].
  • In vitro cathepsin B redistribution also occurs when rat pancreatic fragments are incubated with plasma obtained from opossums with hemorrhagic necrotizing pancreatitis caused by bile/pancreatic duct ligation [7].
  • As a result, lysosomal hydrolases such as cathepsin B are redistributed to the subcellular zymogen granule-rich fraction and lysosomal hydrolases as well as digestive enzyme zymogens are colocalized within large cytoplasmic vacuoles [7].

Chemical compound and disease context of Ctsb


Biological context of Ctsb


Anatomical context of Ctsb


Associations of Ctsb with chemical compounds


Regulatory relationships of Ctsb


Other interactions of Ctsb


Analytical, diagnostic and therapeutic context of Ctsb

  • Immunogold/electron microscopy showed specific staining for cathepsin B only in lysosome-like structures in cells of the mononuclear cell infiltrate in injured muscle [17].
  • In the regressing prostate, RSG-2 mRNA levels peak at 3-4 days after castration, at the time that tissue regression is maximal [13].
  • METHODS: Cathepsin B was identified in rat ocular tissues by Western blotting and immunohistochemistry [28].
  • Cathepsin B, L and H were also detected by using an immunoblotting procedure in which their bands were expressed after differentiation was induced by the increasing calcium concentration [21].
  • Hepatic collagenase activity was similar to the control; however, hepatic cathepsin B and cathepsin L activity and the intracellular degradation of newly synthesized collagen were markedly decreased 3, 5, and 7 days after partial hepatectomy compared with the controls [29].


  1. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky, H.S., Swarts, J.D., Hebda, P.A., Doyle, W.J. Laryngoscope (2004) [Pubmed]
  2. Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats. Ellis, R.C., Earnhardt, J.N., Hayes, R.L., Wang, K.K., Anderson, D.K. J. Neurochem. (2004) [Pubmed]
  3. Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat. Ellis, R.C., O'Steen, W.A., Hayes, R.L., Nick, H.S., Wang, K.K., Anderson, D.K. Exp. Neurol. (2005) [Pubmed]
  4. Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats. Tsubokawa, T., Solaroglu, I., Yatsushige, H., Cahill, J., Yata, K., Zhang, J.H. Stroke (2006) [Pubmed]
  5. Role of cysteine proteases and protease inhibitors in gastric mucosal damage induced by ethanol or ammonia in the rat. Nagy, L., Kusstatscher, S., Hauschka, P.V., Szabo, S. J. Clin. Invest. (1996) [Pubmed]
  6. Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. Mitch, W.E., Medina, R., Grieber, S., May, R.C., England, B.K., Price, S.R., Bailey, J.L., Goldberg, A.L. J. Clin. Invest. (1994) [Pubmed]
  7. A plasma protease which is expressed during supramaximal stimulation causes in vitro subcellular redistribution of lysosomal enzymes in rat exocrine pancreas. Saluja, M., Saluja, A., Lerch, M.M., Steer, M.L. J. Clin. Invest. (1991) [Pubmed]
  8. Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat. Ruff, R.L., Secrist, D. J. Clin. Invest. (1984) [Pubmed]
  9. Effects of ethanol and protein deficiency on pancreatic digestive and lysosomal enzymes. Apte, M.V., Wilson, J.S., Korsten, M.A., McCaughan, G.W., Haber, P.S., Pirola, R.C. Gut (1995) [Pubmed]
  10. Cathepsin B and L in nephron segments of rats with puromycin aminonucleoside nephrosis. Olbricht, C.J., Cannon, J.K., Tisher, C.C. Kidney Int. (1987) [Pubmed]
  11. Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis. Ahmed, N.K., Martin, L.A., Watts, L.M., Palmer, J., Thornburg, L., Prior, J., Esser, R.E. Biochem. Pharmacol. (1992) [Pubmed]
  12. Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection. Hayes, D.J., Stubberfield, C.R., McBride, J.D., Wilson, D.L. Infect. Immun. (1991) [Pubmed]
  13. Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands. Guenette, R.S., Mooibroek, M., Wong, K., Wong, P., Tenniswood, M. Eur. J. Biochem. (1994) [Pubmed]
  14. Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Law, R.H., Smooker, P.M., Irving, J.A., Piedrafita, D., Ponting, R., Kennedy, N.J., Whisstock, J.C., Pike, R.N., Spithill, T.W. Infect. Immun. (2003) [Pubmed]
  15. The activities of thiol proteases in the rat visceral yolk sac increase during late gestation. Grubb, J.D., Koszalk, T.R., Drabick, J.J., Metrione, R.M. Placenta (1991) [Pubmed]
  16. Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. Linke, M., Herzog, V., Brix, K. J. Cell. Sci. (2002) [Pubmed]
  17. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges, M.C., Balcerzak, D., Fisher, B.D., Attaix, D., Béchet, D., Ferrara, M., Baracos, V.E. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  18. Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. Jia, Z., Hasnain, S., Hirama, T., Lee, X., Mort, J.S., To, R., Huber, C.P. J. Biol. Chem. (1995) [Pubmed]
  19. Cysteine proteinase content of rat muscle lysosomes. Evidence for an unusual proteinase activity. Obled, A., Ouali, A., Valin, C. Biochimie (1984) [Pubmed]
  20. Characterisation of a cysteine protease from bloodstream forms of Trypanosoma congolense. Mbawa, Z.R., Gumm, I.D., Shaw, E., Lonsdale-Eccles, J.D. Eur. J. Biochem. (1992) [Pubmed]
  21. Changes of lysosomal proteinase activities and their expression in rat cultured keratinocytes during differentiation. Tanabe, H., Kumagai, N., Tsukahara, T., Ishiura, S., Kominami, E., Nishina, H., Sugita, H. Biochim. Biophys. Acta (1991) [Pubmed]
  22. Microglial secreted cathepsin B induces neuronal apoptosis. Kingham, P.J., Pocock, J.M. J. Neurochem. (2001) [Pubmed]
  23. Thyrotrophin, forskolin and ionomycin increase cathepsin B mRNA concentrations in rat thyroid cells in culture. Phillips, I.D., Black, E.G., Sheppard, M.C., Docherty, K. J. Mol. Endocrinol. (1989) [Pubmed]
  24. Proteolytic enzymes in experimental spinal cord injury. Banik, N.L., Hogan, E.L., Powers, J.M., Smith, K.P. J. Neurol. Sci. (1986) [Pubmed]
  25. Effect of ethanol on pancreatic lysosomes in rats: a possible mechanism for alcoholic pancreatitis. Hirano, T., Manabe, T. Nippon geka hokan. Archiv für japanische Chirurgie. (1993) [Pubmed]
  26. Homology of amino acid sequences of rat liver cathepsins B and H with that of papain. Takio, K., Towatari, T., Katunuma, N., Teller, D.C., Titani, K. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  27. Cathepsins B and H from porcine spleen. Purification, polypeptide chain arrangements, and carbohydrate content. Takahashi, T., Dehdarani, A.H., Schmidt, P.G., Tang, J. J. Biol. Chem. (1984) [Pubmed]
  28. Cathepsin B in the rat eye. Wassélius, J., Wallin, H., Abrahamson, M., Ehinger, B. Graefes Arch. Clin. Exp. Ophthalmol. (2003) [Pubmed]
  29. Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy. Yamamoto, H., Murawaki, Y., Kawasaki, H. Hepatology (1995) [Pubmed]
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