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Gene Review

Ctsl  -  cathepsin L

Rattus norvegicus

Synonyms: CATHL, CP-2, CatL, Cathepsin L, Cathepsin L1, ...
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Disease relevance of Ctsl


Psychiatry related information on Ctsl

  • Thus, the results from this study demonstrate that beta-amyloid impacts on cathepsin-L as an upstream event in the neurodegenerative process and this result highlights the potential role of lysosomal components in the pathogenesis of Alzheimer's disease [6].

High impact information on Ctsl

  • The 28- and 38-kD proteins were shown to be identical to the tissue inhibitor of metalloproteinase-1 (TIMP-1) and the proenzyme form of cathepsin L, respectively [7].
  • This intermediate compartment contained only small amounts of cathepsin L in comparison to lysosomes and was bound by a double membrane, typical of nascent vacuoles [8].
  • Reduced cathepsin L activity, increased numbers of lysosomes, and the formation of meganeurites are all reported to occur during brain aging; thus, it is possible that the infusion of ZPAD into cultured slices sets in motion a greatly accelerated gerontological sequence [9].
  • Hepatic collagenase activity was similar to the control; however, hepatic cathepsin B and cathepsin L activity and the intracellular degradation of newly synthesized collagen were markedly decreased 3, 5, and 7 days after partial hepatectomy compared with the controls [10].
  • Furthermore the mature 29-kDa single-chain and 22-kDa heavy-chain forms of cathepsin L were undetectable in endosomes, although high levels of the 37-kDa proform were observed [11].

Chemical compound and disease context of Ctsl


Biological context of Ctsl


Anatomical context of Ctsl


Associations of Ctsl with chemical compounds

  • On gene array analysis, cathepsin L's message abundance was significantly increased by dexamethasone, and, by in vitro assay, cathepsin L created a 14-kDa carboxyl fragment that corresponded to the sole antigen detected in IEC-18 cell lysates as well as a 16.5-kDa fragment found in the media [18].
  • Epoxy succinate peptide derivatives, CLIK-066, 088, 112, 121, 148, 181, 185 and 187, are typical specific inhibitors for cathepsin L. Aldehyde derivatives CLIK-060 and CLIK-164 showed specific inhibition against cathepsin S and cathepsin K, respectively [2].
  • In addition, by using CM-cellulose column chromatography, cathepsin B and L were separated and the level of cathepsin L activity increased significantly [19].
  • The sequence of rat liver cathepsin L determined at the protein level was identical with that deduced from the cDNA sequence except that in the heavy chain, residues 176-177 (Asp-Ser) were not present at the C-terminus and alanine was replaced by proline at residue 125 [20].
  • The precursor showed a single protein band with Mr 39 kDa on SDS/polyacrylamide gel electrophoresis and was immunoreacted with the anti-rat cathepsin L antibody [21].

Regulatory relationships of Ctsl


Other interactions of Ctsl


Analytical, diagnostic and therapeutic context of Ctsl


  1. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky, H.S., Swarts, J.D., Hebda, P.A., Doyle, W.J. Laryngoscope (2004) [Pubmed]
  2. Study of the functional share of lysosomal cathepsins by the development of specific inhibitors. Katunuma, N., Matsui, A., Kakegawa, T., Murata, E., Asao, T., Ohba, Y. Adv. Enzyme Regul. (1999) [Pubmed]
  3. The 5'-upstream region of the rat phospholipase C-beta 3 gene contains two critical Sp1 sites and an HIV Inr-like element. Kang, J.S., Lee, H.B., Rhee, S.G., Park, K., Yoo, O.J. Gene (1997) [Pubmed]
  4. Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting. Deval, C., Mordier, S., Obled, C., Bechet, D., Combaret, L., Attaix, D., Ferrara, M. Biochem. J. (2001) [Pubmed]
  5. Reconstruction of alveolar bone defect by calcium phosphate compounds. Yoshikawa, M., Toda, T. J. Biomed. Mater. Res. (2000) [Pubmed]
  6. Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. Boland, B., Campbell, V. Neurobiol. Aging (2004) [Pubmed]
  7. Identification of a stimulator of steroid hormone synthesis isolated from testis. Boujrad, N., Ogwuegbu, S.O., Garnier, M., Lee, C.H., Martin, B.M., Papadopoulos, V. Science (1995) [Pubmed]
  8. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. Dunn, W.A. J. Cell Biol. (1990) [Pubmed]
  9. Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. Bednarski, E., Ribak, C.E., Lynch, G. J. Neurosci. (1997) [Pubmed]
  10. Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy. Yamamoto, H., Murawaki, Y., Kawasaki, H. Hepatology (1995) [Pubmed]
  11. Proteolysis of glucagon within hepatic endosomes by membrane-associated cathepsins B and D. Authier, F., Mort, J.S., Bell, A.W., Posner, B.I., Bergeron, J.J. J. Biol. Chem. (1995) [Pubmed]
  12. A possible alternative mechanism of kinin generation in vivo by cathepsin L. Puzer, L., Vercesi, J., Alves, M.F., Barros, N.M., Araujo, M.S., Aparecida Juliano, M., Reis, M.L., Juliano, L., Carmona, A.K. Biol. Chem. (2005) [Pubmed]
  13. Mutagenicity of 2-methylpropene (isobutene) and its epoxide in a modified Salmonella assay for volatile compounds. Cornet, M., Castelain, P., Vercruysse, A., Laib, R., Kirsch-Volders, M., Rogiers, V. Mutat. Res. (1992) [Pubmed]
  14. The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Jones, H.B., Garside, D.A., Liu, R., Roberts, J.C. Exp. Mol. Pathol. (1993) [Pubmed]
  15. Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection. Hayes, D.J., Stubberfield, C.R., McBride, J.D., Wilson, D.L. Infect. Immun. (1991) [Pubmed]
  16. A GC-box within the proximal promoter region of the rat cathepsin L gene activates transcription in Sertoli cells of sexually mature rats. Charron, M., DeCerbo, J.N., Wright, W.W. Biol. Reprod. (2003) [Pubmed]
  17. Cyclic protein-2, a secretory product of rat Sertoli cells, is the proenzyme form of cathepsin L. Erickson-Lawrence, M., Zabludoff, S.D., Wright, W.W. Mol. Endocrinol. (1991) [Pubmed]
  18. A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells. Gordon, P.V., Paxton, J.B., Kuemmerle, J.F., Fox, N.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  19. Changes of lysosomal proteinase activities and their expression in rat cultured keratinocytes during differentiation. Tanabe, H., Kumagai, N., Tsukahara, T., Ishiura, S., Kominami, E., Nishina, H., Sugita, H. Biochim. Biophys. Acta (1991) [Pubmed]
  20. Amino acid sequence of rat liver cathepsin L. Towatari, T., Katunuma, N. FEBS Lett. (1988) [Pubmed]
  21. Precursor of rat epidermal cathepsin L: purification and immunohistochemical localization. Kawada, A., Hara, K., Kominami, E., Tezuka, T., Takahashi, M., Takahara, H. J. Dermatol. Sci. (2000) [Pubmed]
  22. Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells. Collette, J., Ulku, A.S., Der, C.J., Jones, A., Erickson, A.H. Int. J. Cancer (2004) [Pubmed]
  23. Evidence for cross-talk between Sertoli and germ cells using selected cathepsins as markers. Chung, S.S., Zhu, L.J., Mo, M.Y., Silvestrini, B., Lee, W.M., Cheng, C.Y. J. Androl. (1998) [Pubmed]
  24. Interleukin-4 and -13 promote basolateral secretion of H(+) and cathepsin L by glomerular epithelial cells. Van Den Berg, J.G., Aten, J., Annink, C., Ravesloot, J.H., Weber, E., Weening, J.J. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  25. Linkage between phosphorylated cystatin alpha and filaggrin by epidermal transglutaminase as a model of cornified envelope and inhibition of cathepsin L activity by cornified envelope and the conjugated cystatin alpha. Takahashi, M., Tezuka, T., Kakegawa, H., Katunuma, N. FEBS Lett. (1994) [Pubmed]
  26. Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. Tsuji, A., Akamatsu, T., Nagamune, H., Matsuda, Y. Biochem. J. (1994) [Pubmed]
  27. Synthesis of mRNAs for cathepsins L and K during development of the rat mandibular condylar cartilage. Ohba, T., Ohba, Y., Moriyama, K. Cell Tissue Res. (2000) [Pubmed]
  28. Cathepsin L. A new proteinase from rat-liver lysosomes. Kirschke, H., Langner, J., Wiederanders, B., Ansorge, S., Bohley, P. Eur. J. Biochem. (1977) [Pubmed]
  29. Cysteine proteinases in rat dorsal root ganglion and spinal cord, with special reference to the co-localization of these enzymes with calcitonin gene-related peptide in lysosomes. Taniguchi, K., Tomita, M., Kominami, E., Uchiyama, Y. Brain Res. (1993) [Pubmed]
  30. Purification and tissue distribution of rat cathepsin L. Bando, Y., Kominami, E., Katunuma, N. J. Biochem. (1986) [Pubmed]
  31. Expression of cysteine proteinases and their inhibitor, cystatin beta, in cultured rat mesangial cells. Makita, Y., Ishidoh, K., Kominami, E., Funabiki, K., Koide, H., Tomino, Y. J. Diabetes Complicat. (1998) [Pubmed]
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