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Tretinoin toxicity in children with acute promyelocytic leukaemia.

Tretinoin is effective in acute promyelocytic leukaemia in adults. Data about its efficacy and safety in children are limited. We have treated 9 children with tretinoin at 45 mg/m2 per day. Pseudotumour cerebri or hyperleucocytosis occurred in 5 patients. Retinoic acid syndrome was seen in 3 cases. 1 of 2 children who developed hyperleucocytosis, pseudotumour cerebri, and retinoic acid syndrome died despite steroids and mechanical ventilation. Complete remissions with tretinoin alone were achieved in 15 patients. All 8 surviving children received consolidation chemotherapy. Our experience with tretinoin therapy suggests that toxicity is frequent in children.[1]

References

  1. Tretinoin toxicity in children with acute promyelocytic leukaemia. Mahmoud, H.H., Hurwitz, C.A., Roberts, W.M., Santana, V.M., Ribeiro, R.C., Krance, R.A. Lancet (1993) [Pubmed]
 
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