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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor.

The human OX-40 cell surface antigen is a CD4+ T cell activation marker that acts as a costimulatory receptor and is a member of the nerve growth factor receptor/tumor necrosis factor ( TNF) receptor family. Using a soluble form of the receptor, the extracellular region fused with human immunoglobulin Fc, we expression cloned the human OX-40 ligand cDNA from a library derived from an activated B lymphoblastoid cell line MSAB. The encoded protein is identified as gp34, a type II transmembrane antigen previously known to be expressed only by human T cell lymphotropic virus 1-infected cells. We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation.[1]

References

  1. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. Godfrey, W.R., Fagnoni, F.F., Harara, M.A., Buck, D., Engleman, E.G. J. Exp. Med. (1994) [Pubmed]
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