The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The oxidation of alpha-tocopherol and trolox by peroxynitrite.

Peroxynitrite reacts rapidly with alpha-tocopherol to generate a mixture of species. The predominant products are 8a-methoxytocopherone in methanol and alpha-tocopherylquinone in acetonitrile. Only a small fraction (about 2% of original alpha-tocopherol) was detected as alpha-tocopheroxyl radical in either solvent. We propose that peroxynitrite oxidizes alpha-tocopherol in a two-electron process yielding the alpha-tocopherone cation. The two-electron oxidation may be either concerted or sequential. The fate of the alpha-tocopherone cation is solvent dependent. In acetonitrile it undergoes hydrolysis, in the presence of trace amounts of water, to form alpha-tocopherylquinone. In methanol it undergoes nucleophilic addition to yield 8a-methoxytocopherone. Our data suggest that two-electron oxidation of alpha-tocopherol by peroxynitrite represents the major pathway, whereas one-electron oxidation to generate alpha-tocopheroxyl radical is a minor pathway. The biological consequences of two-electron oxidation of alpha-tocopherol are discussed.[1]

References

  1. The oxidation of alpha-tocopherol and trolox by peroxynitrite. Hogg, N., Joseph, J., Kalyanaraman, B. Arch. Biochem. Biophys. (1994) [Pubmed]
 
WikiGenes - Universities