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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep.

A full length ovine steroid 11 beta-hydroxylase (cytochrome P-450(11 beta)) cDNA clone from a sheep adrenal cortex cDNA library was isolated. Sequence analysis indicates that this cDNA clone resembles bovine P-450(11 beta) cDNA (95% nucleotide sequence homology) more closely than rat P-450(11 beta) cDNA (69% nucleotide sequence homology). Although the levels of nucleotide sequence homology of this cDNA clone to the rat P-450(11 beta) cDNA and the rat P-450aldo cDNA are similar, the putative amino acid sequence shows a closer resemblance to rat P-450aldo protein. Northern blot analysis shows that there are three sizes of transcript and they are expressed throughout the adrenal cortex.[1]

References

  1. Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep. Boon, W.C., Roche, P.J., Hammond, V.E., Jeyaseelan, K., Crawford, R.J., Coghlan, J.P. Biochim. Biophys. Acta (1995) [Pubmed]
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