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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

Deletion of the promoter and the first exon of the DNA polymerase beta gene ( pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.[1]

References

  1. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Gu, H., Marth, J.D., Orban, P.C., Mossmann, H., Rajewsky, K. Science (1994) [Pubmed]
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