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Gene Review

Polb  -  polymerase (DNA directed), beta

Mus musculus

Synonyms: A430088C08Rik, DNA polymerase beta, Pol beta
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Disease relevance of Polb


High impact information on Polb


Chemical compound and disease context of Polb


Biological context of Polb


Anatomical context of Polb

  • For this purpose, we used mouse embryo fibroblasts derived from wild-type and Polb gene knockout littermates [17].
  • Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally [18].
  • Both wild-type and, in particular, repair-deficient DNA polymerase beta null cells are highly sensitized to the cytotoxic effects of MMS by 4-amino-1,8-naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity [19].
  • Murine Pol lambda, consisting of 573 amino acid residues, has a 32% identity to Pol beta, involved in nuclear DNA repair in eukaryotic cells [20].
  • The effect of the DNA polymerase-beta (beta-pol) deficiency on mitogenic response and cytokine production was studied in spleen lymphocytes from 4-5- and 20-22-month-old beta-pol(-/+) mice and their age-matched wild-type littermates [21].

Associations of Polb with chemical compounds


Physical interactions of Polb


Enzymatic interactions of Polb


Regulatory relationships of Polb


Other interactions of Polb


Analytical, diagnostic and therapeutic context of Polb


  1. The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Trivedi, R.N., Almeida, K.H., Fornsaglio, J.L., Schamus, S., Sobol, R.W. Cancer Res. (2005) [Pubmed]
  2. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Kaina, B., Ochs, K., Grösch, S., Fritz, G., Lips, J., Tomicic, M., Dunkern, T., Christmann, M. Prog. Nucleic Acid Res. Mol. Biol. (2001) [Pubmed]
  3. Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Ochs, K., Sobol, R.W., Wilson, S.H., Kaina, B. Cancer Res. (1999) [Pubmed]
  4. Unique requirements for template primers of DNA polymerase beta from rat ascites hepatoma AH130 cells. Ono, K., Ohashi, A., Tanabe, K., Matsukage, A., Nishizawa, M., Takahashi, T. Nucleic Acids Res. (1979) [Pubmed]
  5. Activation of the mouse DNA polymerase beta gene promoter by adenovirus type 12 E1A proteins. Yamaguchi, M., Hayashi, Y., Hirose, F., Shiroki, K., Matsukage, A. Nucleic Acids Res. (1992) [Pubmed]
  6. Requirement of mammalian DNA polymerase-beta in base-excision repair. Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., Wilson, S.H. Nature (1996) [Pubmed]
  7. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Gu, H., Marth, J.D., Orban, P.C., Mossmann, H., Rajewsky, K. Science (1994) [Pubmed]
  8. Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase. Delarue, M., Boulé, J.B., Lescar, J., Expert-Bezançon, N., Jourdan, N., Sukumar, N., Rougeon, F., Papanicolaou, C. EMBO J. (2002) [Pubmed]
  9. The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells. Clairmont, C.A., Narayanan, L., Sun, K.W., Glazer, P.M., Sweasy, J.B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta. Louat, T., Servant, L., Rols, M.P., Bieth, A., Teissie, J., Hoffmann, J.S., Cazaux, C. Mol. Pharmacol. (2001) [Pubmed]
  11. An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells. Seki, S., Oda, T. Carcinogenesis (1988) [Pubmed]
  12. Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. Moynihan, K., Elion, G.B., Ali-Osman, F., Marcelli, S., Keir, S., Bigner, D.D., Friedman, H.S. Cancer Chemother. Pharmacol. (1996) [Pubmed]
  13. DNA damage by peplomycin and its repair in an in vitro system. Zhang, B., Seki, S., Ikeda, S. Int. J. Biochem. (1991) [Pubmed]
  14. Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Niimi, N., Sugo, N., Aratani, Y., Koyama, H. Cell Death Differ. (2005) [Pubmed]
  15. Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice. Sugo, N., Niimi, N., Aratani, Y., Masutani, M., Suzuki, H., Koyama, H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  16. Murine DNA polymerase beta gene: mapping of transcription initiation sites and the nucleotide sequence of the putative promoter region. Yamaguchi, M., Hirose, F., Hayashi, Y., Nishimoto, Y., Matsukage, A. Mol. Cell. Biol. (1987) [Pubmed]
  17. Biological response to ionizing radiation in mouse embryo fibroblasts with a targeted disruption of the DNA polymerase beta gene. Miura, M., Watanabe, H., Okochi, K., Sasaki, T., Shibuya, H. Radiat. Res. (2000) [Pubmed]
  18. Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. Esposito, G., Texido, G., Betz, U.A., Gu, H., Müller, W., Klein, U., Rajewsky, K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., Wilson, S.H. J. Biol. Chem. (2005) [Pubmed]
  20. DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. García-Díaz, M., Domínguez, O., López-Fernández, L.A., de Lera, L.T., Saníger, M.L., Ruiz, J.F., Párraga, M., García-Ortiz, M.J., Kirchhoff, T., del Mazo, J., Bernad, A., Blanco, L. J. Mol. Biol. (2000) [Pubmed]
  21. Normal immune function in young and old DNA polymerase-beta deficient mice. Pahlavani, M.A., Vargas, D.M., Guo, Z., Richardson, A. Immunol. Lett. (2000) [Pubmed]
  22. Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Sobol, R.W., Kartalou, M., Almeida, K.H., Joyce, D.F., Engelward, B.P., Horton, J.K., Prasad, R., Samson, L.D., Wilson, S.H. J. Biol. Chem. (2003) [Pubmed]
  23. Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency. Cabelof, D.C., Raffoul, J.J., Nakamura, J., Kapoor, D., Abdalla, H., Heydari, A.R. J. Biol. Chem. (2004) [Pubmed]
  24. Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Dantzer, F., de La Rubia, G., Ménissier-De Murcia, J., Hostomsky, Z., de Murcia, G., Schreiber, V. Biochemistry (2000) [Pubmed]
  25. Mammalian base excision repair by DNA polymerases delta and epsilon. Stucki, M., Pascucci, B., Parlanti, E., Fortini, P., Wilson, S.H., Hübscher, U., Dogliotti, E. Oncogene (1998) [Pubmed]
  26. REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. Poltoratsky, V., Horton, J.K., Prasad, R., Wilson, S.H. DNA Repair (Amst.) (2005) [Pubmed]
  27. Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta. Canitrot, Y., Lautier, D., Laurent, G., Fréchet, M., Ahmed, A., Turhan, A.G., Salles, B., Cazaux, C., Hoffmann, J.S. Oncogene (1999) [Pubmed]
  28. Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene. Yamaguchi, M., Hayashi, Y., Matsuoka, S., Takahashi, T., Matsukage, A. Eur. J. Biochem. (1994) [Pubmed]
  29. Aphidicolin-resistant and -sensitive base excision repair in wild-type and DNA polymerase beta-defective mouse cells. Parlanti, E., Pascucci, B., Terrados, G., Blanco, L., Dogliotti, E. DNA Repair (Amst.) (2004) [Pubmed]
  30. Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Parker, W.B., Shaddix, S.C., Chang, C.H., White, E.L., Rose, L.M., Brockman, R.W., Shortnacy, A.T., Montgomery, J.A., Secrist, J.A., Bennett, L.L. Cancer Res. (1991) [Pubmed]
  31. DNA polymerase beta is not essential for the formation of palindromic (P) region of T cell receptor gene. Gonda, H., Sugai, M., Katakai, T., Sugo, N., Aratani, Y., Koyama, H., Mori, K.J., Shimizu, A. Immunol. Lett. (2001) [Pubmed]
  32. Mapping of the gene for DNA polymerase beta to mouse chromosome 8. McBride, O.W., Kozak, C.A., Wilson, S.H. Cytogenet. Cell Genet. (1990) [Pubmed]
  33. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion. Liu, P.K., Hsu, C.Y., Dizdaroglu, M., Floyd, R.A., Kow, Y.W., Karakaya, A., Rabow, L.E., Cui, J.K. J. Neurosci. (1996) [Pubmed]
  34. Difference in the expression level of DNA polymerase beta among mouse tissues: high expression in the pachytene spermatocyte. Hirose, F., Hotta, Y., Yamaguchi, M., Matsukage, A. Exp. Cell Res. (1989) [Pubmed]
  35. DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair. Parsons, J.L., Dianova, I.I., Allinson, S.L., Dianov, G.L. Biochemistry (2005) [Pubmed]
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