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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?

Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.[1]

References

  1. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Tsuda, T., Lopez, R., Rogaeva, E.A., Freedman, M., Rogaev, E., Drachman, D., Pollen, D., Haines, J., Liang, Y., McLachlan, D.R. Ann. Neurol. (1994) [Pubmed]
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