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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.

Regulation of macrophage scavenger receptor ( MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor ( M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.[1]

References

  1. Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function. de Villiers, W.J., Fraser, I.P., Hughes, D.A., Doyle, A.G., Gordon, S. J. Exp. Med. (1994) [Pubmed]
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