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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sucralfate suspension as a treatment of recurrent aphthous stomatitis.

DESIGN. A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial. SETTING. A university hospital. SUBJECTS. Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups. INTERVENTION. In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years. RESULTS. After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission. CONCLUSION. Sucralfate suspension should be added to the armament of treatment modalities of RAS.[1]


  1. Sucralfate suspension as a treatment of recurrent aphthous stomatitis. Rattan, J., Schneider, M., Arber, N., Gorsky, M., Dayan, D. J. Intern. Med. (1994) [Pubmed]
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