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MeSH Review

Stomatitis, Aphthous

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Disease relevance of Stomatitis, Aphthous


High impact information on Stomatitis, Aphthous


Chemical compound and disease context of Stomatitis, Aphthous


Biological context of Stomatitis, Aphthous


Anatomical context of Stomatitis, Aphthous


Gene context of Stomatitis, Aphthous

  • Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF-alpha, TNF-beta and the vitamin D receptor: no association detected [21].
  • In particular, patients with oral aphthous ulcers (n = 51, 34 pg/ml) and neurological features (n = 4, 71 pg/ml) exhibited increased IL-8 levels [22].
  • The levels of IL-4, IL-10 and IL-13 were found to be high in active BD patients, and IL-12 and interferon-gamma levels were lower in active BD patients than in inactive BD, recurrent aphthous stomatitis, and control patients [23].
  • In this study, we investigated the levels of interleukin (IL)-4, IL-10, IL-12, IL-13 and interferon-g in the sera of patients with BD, in comparison with recurrent aphthous stomatitis and healthy controls, to determine the Th1/Th2 profile of the disease [23].
  • No deviations of HLA-A and -B antigens in patients with recurrent aphthous stomatitis [24].

Analytical, diagnostic and therapeutic context of Stomatitis, Aphthous


  1. Nicotine patches for aphthous ulcers due to Behçet's syndrome. Scheid, P., Bohadana, A., Martinet, Y. N. Engl. J. Med. (2000) [Pubmed]
  2. Thalidomide for aphthous ulcers in HIV infection. Birnkrant, D. N. Engl. J. Med. (1997) [Pubmed]
  3. Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. Jacobson, J.M., Greenspan, J.S., Spritzler, J., Ketter, N., Fahey, J.L., Jackson, J.B., Fox, L., Chernoff, M., Wu, A.W., MacPhail, L.A., Vasquez, G.J., Wohl, D.A. N. Engl. J. Med. (1997) [Pubmed]
  4. Thalidomide in low intermittent doses does not prevent recurrence of human immunodeficiency virus-associated aphthous ulcers. Jacobson, J.M., Greenspan, J.S., Spritzler, J., Fox, L., Fahey, J.L., Jackson, J.B., Chernoff, M., Wohl, D.A., Pulvirenti, J.J., Hooton, T.M., Shikuma, C. J. Infect. Dis. (2001) [Pubmed]
  5. Safety, tolerability, and pharmacokinetic effects of thalidomide in patients infected with human immunodeficiency virus: AIDS Clinical Trials Group 267. Wohl, D.A., Aweeka, F.T., Schmitz, J., Pomerantz, R., Cherng, D.W., Spritzler, J., Fox, L., Simpson, D., Bell, D., Holohan, M.K., Thomas, S., Robinson, W., Kaplan, G., Teppler, H. J. Infect. Dis. (2002) [Pubmed]
  6. Phenelzine in the treatment of aphthous ulcers of the mouth. Lejonc, J.L., Fourestie, V. N. Engl. J. Med. (1985) [Pubmed]
  7. Association of major aphthous ulcers and nicorandil. Agbo-Godeau, S., Joly, P., Lauret, P., Szpirglas, R., Szpirglas, H. Lancet (1998) [Pubmed]
  8. Aphthous ulcers of mouth from captopril. Seedat, Y.K. Lancet (1979) [Pubmed]
  9. Use of levamisole in recurrent aphthous stomatitis. Miller, M.F. Drugs (1980) [Pubmed]
  10. Differential efficacy of human recombinant interferon-alpha2a on ocular and extraocular manifestations of Behçet disease: results of an open 4-center trial. Kötter, I., Vonthein, R., Zierhut, M., Eckstein, A.K., Ness, T., Günaydin, I., Grimbacher, B., Blaschke, S., Peter, H.H., Stübiger, N. Semin. Arthritis Rheum. (2004) [Pubmed]
  11. Does phenelzine relieve aphthous ulcers of the mouth? Rosenthal, S.H. N. Engl. J. Med. (1984) [Pubmed]
  12. Sucralfate suspension as a treatment of recurrent aphthous stomatitis. Rattan, J., Schneider, M., Arber, N., Gorsky, M., Dayan, D. J. Intern. Med. (1994) [Pubmed]
  13. Treatment of recurrent aphthous stomatitis with pentoxifylline. Pizarro, A., Navarro, A., Fonseca, E., Vidaurrazaga, C., Herranz, P. Br. J. Dermatol. (1995) [Pubmed]
  14. Acyclovir in the prevention of severe aphthous ulcers. Pedersen, A. Archives of dermatology. (1992) [Pubmed]
  15. Polymorphisms in the IL-10 and IL-12 gene cluster and risk of developing recurrent aphthous stomatitis. Bazrafshani, M.R., Hajeer, A.H., Ollier, W.E., Thornhill, M.H. Oral diseases. (2003) [Pubmed]
  16. Expression of laminin 5, fibronectin, and epithelium-associated integrins in recurrent aphthous ulcers. Richards, D.W., MacPhail, L.A., Dekker, N., Greenspan, D., Greenspan, J.S., Lozada-Nur, F., Regezi, J.A. J. Dent. Res. (1996) [Pubmed]
  17. Thalidomide-resistant HIV-associated aphthae successfully treated with granulocyte colony-stimulating factor. Manders, S.M., Kostman, J.R., Mendez, L., Russin, V.L. J. Am. Acad. Dermatol. (1995) [Pubmed]
  18. Defining a T-cell epitope within HSP 65 in recurrent aphthous stomatitis. Hasan, A., Shinnick, T., Mizushima, Y., van der Zee, R., Lehner, T. Clin. Exp. Immunol. (2002) [Pubmed]
  19. Expression of the CD54 (ICAM-1) and CD11a (LFA-1) adhesion molecules in oral mucosal inflammation. Verdickt, G.M., Savage, N.W., Dodd, N.M., Walsh, L.J. J. Oral Pathol. Med. (1992) [Pubmed]
  20. A case of Behçet's syndrome with supeior vena cava syndrome. Han, D.S., Kim, J.B., Lee, O.Y., Sohn, J.H., Park, K.N., Park, C.K. Korean J. Intern. Med. (1998) [Pubmed]
  21. Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF-alpha, TNF-beta and the vitamin D receptor: no association detected. Bazrafshani, M.R., Hajeer, A.H., Ollier, W.E., Thornhill, M.H. Oral diseases. (2002) [Pubmed]
  22. Adamantiades-Behçet's disease: interleukin-8 is increased in serum of patients with active oral and neurological manifestations and is secreted by small vessel endothelial cells. Zouboulis, C.C., Katsantonis, J., Ketteler, R., Treudler, R., Kaklamani, E., Hornemann, S., Kaklamanis, P., Orfanos, C.E. Arch. Dermatol. Res. (2000) [Pubmed]
  23. Serum Levels of IL-4, IL-10, IL-12, IL-13 and IFN-gamma in Behçet's disease. Aridogan, B.C., Yildirim, M., Baysal, V., Inaloz, H.S., Baz, K., Kaya, S. J. Dermatol. (2003) [Pubmed]
  24. No deviations of HLA-A and -B antigens in patients with recurrent aphthous stomatitis. Platz, P., Ryder, L.P., Donatsky, O. Tissue Antigens (1976) [Pubmed]
  25. Crossover study of thalidomide vs placebo in severe recurrent aphthous stomatitis. Revuz, J., Guillaume, J.C., Janier, M., Hans, P., Marchand, C., Souteyrand, P., Bonnetblanc, J.M., Claudy, A., Dallac, S., Klene, C. Archives of dermatology. (1990) [Pubmed]
  26. Minor recurrent aphthous stomatitis and smoking: an epidemiological study measuring plasma cotinine. Atkin, P.A., Xu, X., Thornhill, M.H. Oral diseases. (2002) [Pubmed]
  27. The effects of a 0.2% chlorhexidine gluconate mouthrinse on plaque, toothstaining and candida in aphthous ulcer patients. A double-blind placebo-controlled cross-over study. Addy, M., Hunter, L. Journal of clinical periodontology. (1987) [Pubmed]
  28. Topical and systemic therapy for recurrent aphthous stomatitis. MacPhail, L. Seminars in cutaneous medicine and surgery. (1997) [Pubmed]
  29. Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers. Häyrinen-Immonen, R., Sorsa, T., Pettilä, J., Konttinen, Y.T., Teronen, O., Malmström, M. J. Oral Pathol. Med. (1994) [Pubmed]
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