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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury.

Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.[1]

References

  1. Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury. Sabesin, S.M., Kuiken, L.B., Ragland, J.B. Science (1975) [Pubmed]
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