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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A mass spectrometric solution to the address problem of combinatorial libraries.

The molecular weights of femtomole quantities of small peptides attached to polystyrene beads have been determined with imaging time-of-flight secondary ion mass spectrometry. The analysis is made possible by the selective clipping of the bond linking the peptide to a bead with trifluoroacetic acid vapor before the secondary ion mass spectrometry assay. The approach can be applied to large numbers of 30- to 60-micrometer polystyrene beads for the direct characterization of massive combinatorial libraries.[1]

References

  1. A mass spectrometric solution to the address problem of combinatorial libraries. Brummel, C.L., Lee, I.N., Zhou, Y., Benkovic, S.J., Winograd, N. Science (1994) [Pubmed]
 
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