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Chemical Compound Review

Trifluoroacetic acid     2,2,2-trifluoroethanoic acid

Synonyms: IPC-PFFA-2, AmbotzSOL-011, BUFFER A, PubChem12671, CF3COOH, ...
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Disease relevance of TRIFLUOROACETATE


Psychiatry related information on TRIFLUOROACETATE


High impact information on TRIFLUOROACETATE

  • The thermolability of HLA-B5 can be overcome by addition of HLA-B5-presentable peptides, obtained by trifluoroacetic acid extraction from an HLA-B5-positive cell line, underlining the necessity of peptide for class I stability and indicating that T2-derived class I complexes are devoid of peptide [7].
  • With reverse-phase HPLC on a C18 column, using 6 M guanidine-HCl solubilization and a 0.1% trifluoroacetic acid/CH3CN gradient system (Stephens, R. E., 1984, J. Cell Biol. 90:37a [Abstr.]), the relatively less hydrophobic 51-kD tektin elutes at greater than 45% CH3CN, immediately followed by the 55-kD chain [8].
  • ARIA was extracted in a trifluoroacetic acid-containing cocktail and purified to homogeneity by reverse-phase, ion exchange, and size exclusion high pressure liquid chromatography [9].
  • When subunits of the purified PDE were separated by reverse-phase HPLC in 0.1% trifluoroacetic acid and acetonitrile, a peak of material having spectral properties characteristic of a guanine ring was seen [10].
  • Oncostatin M is stable between pH 2 and 11 and after heating for 1 hr at 56 degrees C but is not stable at 90 degrees C. Purification of oncostatin M has been achieved by gel chromatography and reversed-phase HPLC, using sequentially acetonitrile and n-propanol in the presence of aqueous trifluoroacetic acid [11].

Chemical compound and disease context of TRIFLUOROACETATE


Biological context of TRIFLUOROACETATE

  • Dionex anion exchange chromatographic analyses of fragments produced by nitrous acid deamination, hydrofluoric acid dephosphorylation, and trifluoroacetic acid hydrolysis in conjunction with biosynthetic labeling studies indicated a structure containing a third EthN-P substituent linked to the 6-position of Man 2 [17].
  • The newly formed reducing termini of HS fragments were then reduced with NaB[3H]4, and the fragments hydrolyzed to monosaccharides by trifluoroacetic acid treatment and nitrous acid deamination [18].
  • Selected peptides were rechromatographed in 0.1% trifluoroacetic acid, and their amino acid sequences were determined [19].
  • Treatment of 18 with CF3COOH/CHCl3 caused deisopropylidenation with simultaneous cyclization into the desired 6-(beta-D-ribofuranosyl)picolinamide (8) [20].
  • Direct acetylation of isoproterenol by selective O-acetylation using CH3COCl/CF3COOH was shown to lead to the formation of 2-(3,4-diacetoxyphenyl)-2-chloro-N-isopropyl-1-ethanamine and not to 3,4-O-diacetylisoproterenol [21].

Anatomical context of TRIFLUOROACETATE


Associations of TRIFLUOROACETATE with other chemical compounds




Analytical, diagnostic and therapeutic context of TRIFLUOROACETATE


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  18. Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. Nakajima, M., Irimura, T., Di Ferrante, N., Nicolson, G.L. J. Biol. Chem. (1984) [Pubmed]
  19. The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence. van Driel, I.R., Stearne, P.A., Grego, B., Simpson, R.J., Goding, J.W. J. Immunol. (1984) [Pubmed]
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