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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tibial hemimelia and tetralogy of Fallot associated with first trimester exposure to amantadine.

Although amantadine hydrochloride has been extensively used for the prevention of influenza A2, few data exist regarding its safety in pregnancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 29 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follow-up of the four prospective cases known to date to the Motherisk Program in Toronto did not identify any abnormalities.[1]

References

  1. Tibial hemimelia and tetralogy of Fallot associated with first trimester exposure to amantadine. Pandit, P.B., Chitayat, D., Jefferies, A.L., Landes, A., Qamar, I.U., Koren, G. Reprod. Toxicol. (1994) [Pubmed]
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