Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Jorm, C.M. et al.

Early age-dependent changes in noradrenaline efflux in the bed nucleus of stria terminalis: voltammetric data in rat brain slices.

Fast cyclic voltammetry (FCV) was applied to the detection of stimulated noradrenaline (NA) efflux in the bed nucleus of stria terminalis (BSTV) of the superfused rat brain slice from rats of different ages. Three age groups were compared: young (5 weeks; 130 +/- 8 g), adult (12 weeks; 308 +/- 12 g), and mature rats (36 weeks; 575 +/- 21 g). The effect of train duration (20-99 pulses at 100 Hz) and frequency of stimulation (50 pulses at 10-500 Hz) on NA efflux were examined. The effect of the alpha 2 antagonist yohimbine (1 microM) was also investigated. NA efflux was significantly (p < 0.05) greater in young than adult or mature rats on all train durations and stimulus frequencies tested: Maximal NA efflux on the longest train (99 pulses, 100 Hz, 10 mA, 0.2 ms) was 423 +/- 48 nM (young), 135 +/- 24 nM (adult), and 155 +/- 26 nM (mature). There were no significant differences between adult and mature rats. Yohimbine (1 microM) elevated NA efflux to a greater extent at lower (10 & 20 Hz) than higher frequencies in all age groups. Yohimbine also potentiated NA efflux more (p < 0.05) in young and adult rats than in mature animals. There were no significant differences between young and adult rats. The results indicate early maturational differences in both NA efflux and its control by alpha 2 adrenoceptors. Interestingly, the decreases in NA efflux and in yohimbine response were not temporally linked.[1]

References

Early age-dependent changes in noradrenaline efflux in the bed nucleus of stria terminalis: voltammetric data in rat brain slices. Jorm, C.M., Stamford, J.A. Neurobiol. Aging (1993) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.