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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism.

A 57-year-old woman with hypertension and moderate renal insufficiency had chronic unexplained hyperkalaemia. Metabolic balance studies confirmed a diagnosis of hyporeninaemic hypoaldosteronism. Two observations suggested that impaired renal prostaglandin production contributed to the pathogenesis of the patient's disorder. Baseline renal-prostaglandin synthesis (as determined by urinary excretion of P.G.E and P.G.F) was was substantially depressed when compared with that in nine normal females. Infusion of low doses of P.G.A1 produced a significant increase in serum-aldosterone and urinary potassium excretion; it also led to a dramatic fall in blood-pressure and serum-potassium. It appears from these studies that a defect in renal prostaglandin synthesis has an important role in the pathogenesis of hyporeninaemic hypoaldosteronism.[1]

References

  1. Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism. Norby, L.H., Weidig, J., Ramwell, P., Slotkoff, L., Flamenbaum, W. Lancet (1978) [Pubmed]
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