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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A randomized trial of three oral contraceptives: comparison of bleeding patterns by contraceptive types and steroid levels.

OBJECTIVE: Our purpose was to determine the relationship between bioavailability of contraceptive steroids and bleeding patterns. STUDY DESIGN: A randomized clinical trial evaluated 192 women on 50 micrograms of ethinyl estradiol and 1.0 mg of norethindrone (OC1), 35 micrograms ethinyl estradiol and 1.0 mg of norethindrone ( OC2), and 35 micrograms ethinyl estradiol and 0.5 mg norethindrone (OC3) over nine cycles. RESULTS: Intermenstrual bleeding rates were higher for OC3 when compared with OC1 (p = 0.01). The number of intermenstrual bleeding days was highest for OC3 (p = 0.001) and higher for OC2 when compared with OC1 (p < 0.006). The onset of withdrawal bleeding occurred faster in OC3 patients (p < 0.02). Bioavailability of both contraceptive steroids as measured by baseline values and 1-hour slopes did not correlate with bleeding patterns at 3, 6, and 9 months of use. CONCLUSION: These data suggest that differences in biologic responses associated with pill use cannot be explained solely on the basis of these particular hormone measurements.[1]

References

  1. A randomized trial of three oral contraceptives: comparison of bleeding patterns by contraceptive types and steroid levels. Saleh, W.A., Burkman, R.T., Zacur, H.A., Kimball, A.W., Kwiterovich, P., Bell, W.K. Am. J. Obstet. Gynecol. (1993) [Pubmed]
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