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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Involvement of nitric oxide on the cytokine induced growth of glial cell.

The growth of C6 glioma cells was stimulated by TNF-alpha, IFN-gamma and IL-6 but not by TNF-beta. However, TNF-alpha and IFN-gamma but not IL-6 induced the synthesis of NO in C6 cells. Moreover, N-monomethyl-L-arginine a competitive inhibitor of NO synthase blocked TNF-alpha and IFN-gamma-dependent proliferation and NO induction on C6 cells, but had no effect on IL-6-dependent proliferation. In addition, C6 proliferation induced by TNF-alpha and IFN-gamma was specifically blocked by inhibitors of cyclic nucleotide dependent protein kinases such us H-9. Those results suggest that TNF-alpha and IFN-gamma but not IL-6 induce the growth of glia cells through the generation of NO which in turns activate a cyclic nucleotide dependent kinase.[1]


  1. Involvement of nitric oxide on the cytokine induced growth of glial cell. Muñoz-Fernández, M.A., Fresno, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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