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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat.

Transitional cell and squamous cell cancer of the bladder was induced in Wistar/Lewis female rats by direct instillation of N-methyl-N-nitrosourea into the bladder. Feeding of the synthetic retinoid, 13-cis-retinoid acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis-retinoic acid administration was begun after completion of the carcinogen treatment.[1]


  1. 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat. Sporn, M.B., Squire, R.A., Brown, C.C., Smith, J.M., Wenk, M.L., Springer, S. Science (1977) [Pubmed]
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