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MeSH Review

Neoplasms, Squamous Cell

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Disease relevance of Neoplasms, Squamous Cell

  • The following antigenic systems were found in lung cancers: a) antigens specific for most squamous cell cancers and adenocarcinomas, which are undetectable in small cell cancers; b) NCA-type antigens; c) CEA-like antigens; and d) the antigen responsible for alpha-1-antichymotrypsin reactivity [1].
  • INTERPRETATION: The risk of squamous cell cancer of the skin is increased by ciclosporin in patients with psoriasis who have been exposed to PUVA [2].
  • Progress in the treatment of advanced squamous cell cancer (SCC) of the head and neck (H & N) has included the development of combination chemotherapeutic regimens that achieve impressive complete response (CR) rates using two to three courses therapy with minimal toxicity and good patient tolerance [3].
  • End points were the development of carcinoma in situ (CIS) or squamous cell cancer (SCC) or the highest category of dysplasia up until March 1, 2003 for the remaining preneoplastic lesions [4].
  • These liposome uptake values mirrored the estimated tumor volumes of the various tumor types (36.2 +/- 18.0 cm3 for squamous cell cancer of the head and neck, 114.5 +/- 42.0 cm3 for lung tumors, and 234.7 +/- 101.4 cm3 for breast tumors) [5].

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Chemical compound and disease context of Neoplasms, Squamous Cell


Biological context of Neoplasms, Squamous Cell


Anatomical context of Neoplasms, Squamous Cell


Gene context of Neoplasms, Squamous Cell


Analytical, diagnostic and therapeutic context of Neoplasms, Squamous Cell


Chemical compound and disease context of Neoplasms, Squamous Cell

  • PET/CT improves the sensitivity, accuracy, and negative predictive value of 18F-FDG imaging in the assessment of locoregional lymph nodes in thoracic esophageal squamous cell cancer and provides data of diagnostic significance [36].


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  3. An intensive, five course, alternating combination chemotherapy induction regimen used in patients with advanced, unresectable head and neck cancer. Ensley, J., Kish, J., Tapazoglou, E., Jacobs, J., Weaver, A., Atkinson, D., Ahmed, K., Mathog, R., Al-Sarraf, M. J. Clin. Oncol. (1988) [Pubmed]
  4. The natural course of preneoplastic lesions in bronchial epithelium. Breuer, R.H., Pasic, A., Smit, E.F., van Vliet, E., Vonk Noordegraaf, A., Risse, E.J., Postmus, P.E., Sutedja, T.G. Clin. Cancer Res. (2005) [Pubmed]
  5. Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Harrington, K.J., Mohammadtaghi, S., Uster, P.S., Glass, D., Peters, A.M., Vile, R.G., Stewart, J.S. Clin. Cancer Res. (2001) [Pubmed]
  6. Diet and lung cancer risk: findings from the Western New York Diet Study. Byers, T.E., Graham, S., Haughey, B.P., Marshall, J.R., Swanson, M.K. Am. J. Epidemiol. (1987) [Pubmed]
  7. a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Khuri, F.R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I.F., Romel, L., Gore, M., Ironside, J., MacDougall, R.H., Heise, C., Randlev, B., Gillenwater, A.M., Bruso, P., Kaye, S.B., Hong, W.K., Kirn, D.H. Nat. Med. (2000) [Pubmed]
  8. 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat. Sporn, M.B., Squire, R.A., Brown, C.C., Smith, J.M., Wenk, M.L., Springer, S. Science (1977) [Pubmed]
  9. Pathology of esophageal neoplasms and associated proliferative lesions induced in rats by N-methyl-N-benzylnitrosamine. Stinson, S.F., Squire, R.A., Sporn, M.B. J. Natl. Cancer Inst. (1978) [Pubmed]
  10. Thioproline in squamous cell cancer. Sappino, A.P., Smith, I.E. Lancet (1980) [Pubmed]
  11. A prospective evaluation of 5-fluorouracil plus cisplatin in advanced squamous-cell cancer of the head and neck. Dasmahapatra, K.S., Citrin, P., Hill, G.J., Yee, R., Mohit-Tabatabai, M.A., Rush, B.F. J. Clin. Oncol. (1985) [Pubmed]
  12. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. Soulieres, D., Senzer, N.N., Vokes, E.E., Hidalgo, M., Agarwala, S.S., Siu, L.L. J. Clin. Oncol. (2004) [Pubmed]
  13. A phase I-II trial of cisplatin and dichloromethotrexate in squamous cell cancer of the head and neck. Wheeler, R.H., Natale, R.B., Roshon, S.G., Baker, S.R. J. Clin. Oncol. (1984) [Pubmed]
  14. Multi-institutional phase I/II trial of oral bexarotene in combination with cisplatin and vinorelbine in previously untreated patients with advanced non-small-cell lung cancer. Khuri, F.R., Rigas, J.R., Figlin, R.A., Gralla, R.J., Shin, D.M., Munden, R., Fox, N., Huyghe, M.R., Kean, Y., Reich, S.D., Hong, W.K. J. Clin. Oncol. (2001) [Pubmed]
  15. Cytochrome p450 and glutathione transferase expression in squamous cell cancer. Ali, S., El-Rayes, B.F., Heilbrun, L.K., Sarkar, F.H., Ensley, J.F., Kucuk, O., Philip, P.A. Clin. Cancer Res. (2004) [Pubmed]
  16. Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer. Chen, L., Matsubara, N., Yoshino, T., Nagasaka, T., Hoshizima, N., Shirakawa, Y., Naomoto, Y., Isozaki, H., Riabowol, K., Tanaka, N. Cancer Res. (2001) [Pubmed]
  17. Gene therapy--phase I trial for primary untreated head and neck squamous cell cancer (HNSCC) UICC stage II-IV with a single intratumoral injection of hIL-2 plasmids formulated in DOTMA/Chol. Wollenberg, B., Kastenbauer, n.u.l.l., Mundl, H., Schaumberg, J., Mayer, A., Andratschke, M., Lang, S., Pauli, C., Zeidler, R., Ihrler, S., Löhrs, n.u.l.l., Naujoks, K., Rollston, R. Hum. Gene Ther. (1999) [Pubmed]
  18. Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations. Boyle, J.O., Lonardo, F., Chang, J.H., Klimstra, D., Rusch, V., Dmitrovsky, E. Clin. Cancer Res. (2001) [Pubmed]
  19. Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. Müller-Decker, K., Reinerth, G., Krieg, P., Zimmermann, R., Heise, H., Bayerl, C., Marks, F., Fürstenberger, G. Int. J. Cancer (1999) [Pubmed]
  20. ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer. Casson, A.G., Wilson, S.M., McCart, J.A., O'Malley, F.P., Ozcelik, H., Tsao, M.S., Chambers, A.F. Int. J. Cancer (1997) [Pubmed]
  21. Phase II randomized trial of cisplatin chemotherapy regimens in the treatment of recurrent or metastatic squamous cell cancer of the cervix: a Southwest Oncology Group Study. Alberts, D.S., Kronmal, R., Baker, L.H., Stock-Novack, D.L., Surwit, E.A., Boutselis, J.G., Hannigan, E.V. J. Clin. Oncol. (1987) [Pubmed]
  22. Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation. Aebersold, D.M., Kollar, A., Beer, K.T., Laissue, J., Greiner, R.H., Djonov, V. Int. J. Cancer (2001) [Pubmed]
  23. Studies of cellular retinol-binding protein (CRBP) in squamous-cell carcinomas of the head and neck region. Fex, G., Wahlberg, P., Biörklund, A., Wennerberg, J., Willén, R. Int. J. Cancer (1986) [Pubmed]
  24. BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas. MPT Collaborators, St George's Hospital Collaborators. Gill, S., Broni, J., Jefferies, S., Osin, P., Kovacs, G., Maitland, N.J., Eeles, R., Edwards, S.M., Dyer, M.J., Willis, T.G., Cooper, C.S. Br. J. Cancer (1999) [Pubmed]
  25. Cellular localisation of tumour antigen (TA-4) in normal, dysplastic and neoplastic squamous epithelia of the upper aerodigestive tract. Kearsley, J.H., Stenzel, D.J., Sculley, T.B., Cooke, R.A. Br. J. Cancer (1990) [Pubmed]
  26. Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors. Pentland, A.P., Scott, G., VanBuskirk, J., Tanck, C., LaRossa, G., Brouxhon, S. Cancer Res. (2004) [Pubmed]
  27. Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Ko, Y., Abel, J., Harth, V., Bröde, P., Antony, C., Donat, S., Fischer, H.P., Ortiz-Pallardo, M.E., Thier, R., Sachinidis, A., Vetter, H., Bolt, H.M., Herberhold, C., Brüning, T. Cancer Res. (2001) [Pubmed]
  28. Differential expression of matrilysin-1 (MMP-7), 92 kD gelatinase (MMP-9), and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer. Impola, U., Uitto, V.J., Hietanen, J., Hakkinen, L., Zhang, L., Larjava, H., Isaka, K., Saarialho-Kere, U. J. Pathol. (2004) [Pubmed]
  29. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Uemura, Y., Pak, S.C., Luke, C., Cataltepe, S., Tsu, C., Schick, C., Kamachi, Y., Pomeroy, S.L., Perlmutter, D.H., Silverman, G.A. Int. J. Cancer (2000) [Pubmed]
  30. Relative levels of SCCA2 and SCCA1 mRNA in primary tumors predicts recurrent disease in squamous cell cancer of the head and neck. Stenman, J., Hedström, J., Grénman, R., Leivo, I., Finne, P., Palotie, A., Orpana, A. Int. J. Cancer (2001) [Pubmed]
  31. Multicenter phase I-II trial of docetaxel, cisplatin, and fluorouracil induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck. Posner, M.R., Glisson, B., Frenette, G., Al-Sarraf, M., Colevas, A.D., Norris, C.M., Seroskie, J.D., Shin, D.M., Olivares, R., Garay, C.A. J. Clin. Oncol. (2001) [Pubmed]
  32. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. Pearcey, R., Brundage, M., Drouin, P., Jeffrey, J., Johnston, D., Lukka, H., MacLean, G., Souhami, L., Stuart, G., Tu, D. J. Clin. Oncol. (2002) [Pubmed]
  33. Interleukin 2 gene transfer prevents NKG2D suppression and enhances antitumor efficacy in combination with cisplatin for head and neck squamous cell cancer. Li, D., Ronson, B., Guo, M., Liu, S., Bishop, J.S., Van Echo, D.A., O'Malley, B.W. Cancer Res. (2002) [Pubmed]
  34. Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic acid) in human oral squamous carcinoma xenografts in nude mice. Shalinsky, D.R., Bischoff, E.D., Gregory, M.L., Lamph, W.W., Heyman, R.A., Hayes, J.S., Thomazy, V., Davies, P.J. Clin. Cancer Res. (1996) [Pubmed]
  35. Induction chemotherapy with cisplatin and continuous infusion 5-fluorouracil in locally far-advanced head and neck cancer. Verweij, J., de Jong, P.C., de Mulder, P.H., van der Broek, P., Alexieva-Figusch, J., van Putten, W.L., Schornagel, J.H., Ravasz, L.A., Snow, G.B., Vermorken, J.B. Am. J. Clin. Oncol. (1989) [Pubmed]
  36. Additional value of PET/CT over PET in assessment of locoregional lymph nodes in thoracic esophageal squamous cell cancer. Yuan, S., Yu, Y., Chao, K.S., Fu, Z., Yin, Y., Liu, T., Chen, S., Yang, X., Yang, G., Guo, H., Yu, J. J. Nucl. Med. (2006) [Pubmed]
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