The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Activation of Ca2+ release from sarcoplasmic reticulum vesicles by 4-alkylphenols.

4-Alkylphenols induce Ca2+ release from junctional (terminal cisternae) sarcoplasmic reticulum vesicles, but not from nonjunctional sarcoplasmic reticulum vesicles. The 4-alkylphenol concentration required to induce Ca2+ release decreases about threefold for every methylene carbon increase in the alkyl chain length, indicating that the Ca(2+)-releasing potency of 4-alkylphenols is related to their ability to partition into the membrane. The rate and amount of Ca2+ release induced by relatively low 4-octylphenol concentrations (25 nmol/mg protein) are altered by the sarcoplasmic reticulum Ca2+ channel activators, Ca2+ and ATP, and the Ca2+ channel inhibitors, Mg2+ and ruthenium red. Ca2+ release induced by 250 nmol 4-octylphenol/mg protein is much less influenced by Ca2+ channel activators and inhibitors; however, even at this high 4-octylphenol concentration, Ca2+ release is not induced from nonjunctional sarcoplasmic reticulum vesicles. The data indicate that 4-alkylphenols induce Ca2+ release by activating the sarcoplasmic reticulum Ca2+ channel.[1]

References

  1. Activation of Ca2+ release from sarcoplasmic reticulum vesicles by 4-alkylphenols. Beeler, T.J., Gable, K.S. Arch. Biochem. Biophys. (1993) [Pubmed]
 
WikiGenes - Universities