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Chemical Compound Review

p-Octylphenol     4-octylphenol

Synonyms: SureCN18809, CHEMBL195437, QC-607, AG-C-92158, CHEBI:34432, ...
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Disease relevance of C14132


High impact information on C14132


Biological context of C14132


Anatomical context of C14132


Associations of C14132 with other chemical compounds


Gene context of C14132

  • The PCNA indices in adenocarcinomas, hyperplastic lesions, and nonlesional glands in rats treated with DMAB and 4-n-octylphenol were slightly lower than that of the DMAB alone group, but the differences were not statistically significant [1].
  • Furthermore non-halogenated compounds among these phenolic compounds, such as BPA, p-octylphenol, and p-nonylphenol, showed inhibitory effects on the isomerase activity of PDI [14].

Analytical, diagnostic and therapeutic context of C14132


  1. Lack of modifying effects of 4-n-octylphenol on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats. Kohno, H., Tsukio, Y., Yanaida, Y., Tanino, M., Tanaka, T. Ecotoxicol. Environ. Saf. (2002) [Pubmed]
  2. Toxicity on crustaceans and endocrine disrupting activity on Saccharomyces cerevisiae of eight alkylphenols. Isidori, M., Lavorgna, M., Nardelli, A., Parrella, A. Chemosphere (2006) [Pubmed]
  3. Occupational exposure to estrogenic chemicals and the occurrence of breast cancer: an exploratory analysis. Aschengrau, A., Coogan, P.F., Quinn, M., Cashins, L.J. Am. J. Ind. Med. (1998) [Pubmed]
  4. Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Han, B.S., Fukamachi, K., Takasuka, N., Ohnishi, T., Maeda, M., Yamasaki, T., Tsuda, H. Carcinogenesis (2002) [Pubmed]
  5. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Sharpe, R.M., Fisher, J.S., Millar, M.M., Jobling, S., Sumpter, J.P. Environ. Health Perspect. (1995) [Pubmed]
  6. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Ishido, M., Morita, M., Oka, S., Masuo, Y. Regul. Pept. (2005) [Pubmed]
  7. Sulfonation of environmental estrogens by zebrafish cytosolic sulfotransferases. Ohkimoto, K., Sugahara, T., Sakakibara, Y., Suiko, M., Liu, M.Y., Carter, G., Liu, M.C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  8. Effect of 4-octylphenol on germ cell number in cultured human fetal gonads. Bendsen, E., Laursen, S., Olesen, C., Westergaard, L., Andersen, C., Byskov, A. Hum. Reprod. (2001) [Pubmed]
  9. Evaluation of androgen receptor transcriptional activities of bisphenol A, octylphenol and nonylphenol in vitro. Xu, L.C., Sun, H., Chen, J.F., Bian, Q., Qian, J., Song, L., Wang, X.R. Toxicology (2005) [Pubmed]
  10. Activation of Ca2+ release from sarcoplasmic reticulum vesicles by 4-alkylphenols. Beeler, T.J., Gable, K.S. Arch. Biochem. Biophys. (1993) [Pubmed]
  11. Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines. Yoon, K., Pellaroni, L., Ramamoorthy, K., Gaido, K., Safe, S. Mol. Cell. Endocrinol. (2000) [Pubmed]
  12. Glucuronidation of nonylphenol and octylphenol eliminates their ability to activate transcription via the estrogen receptor. Moffat, G.J., Burns, A., Van Miller, J., Joiner, R., Ashby, J. Regulatory toxicology and pharmacology : RTP. (2001) [Pubmed]
  13. Evaluation of acute hepatotoxic effects exerted by environmental estrogens nonylphenol and 4-octylphenol in immature male rats. Zumbado, M., Boada, L.D., Torres, S., Monterde, J.G., Díaz-Chico, B.N., Afonso, J.L., Cabrera, J.J., Blanco, A. Toxicology (2002) [Pubmed]
  14. Inhibitory effects of environmental chemicals on protein disulfide isomerase in vitro. Okada, K., Hiroi, T., Imaoka, S., Funae, Y. Osaka city medical journal. (2005) [Pubmed]
  15. Measurement of estrogenic activity in sediments from Haihe and Dagu River, China. Song, M., Xu, Y., Jiang, Q., Lam, P.K., O'Toole, D.K., Giesy, J.P., Jiang, G. Environment international. (2006) [Pubmed]
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