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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Synaptic target contact enhances presynaptic calcium influx by activating cAMP-dependent protein kinase during synaptogenesis.

Individual dissociated supralateral radular tensor (SLT) muscle fibers were manipulated into contact with fura-2-filled neurites of presynaptic buccal motoneuron 19 from Helisoma in cell culture. Within 30 min of contact, action potential-evoked calcium accumulation was reversibly augmented from 228 +/- 82 nM to 803 +/- 212 nM, an action that was blocked by H-7 (40-100 microM). Calcium accumulation was not augmented when buccal motoneuron 19 contacted muscle or neuronal targets with which it does not form chemical synapses. Addition of pCPTcAMP (500 microM) to cultures reversibly enhanced calcium accumulation. Injection of IP20, a peptide inhibitor of cAMP-dependent protein kinase, prevented pCPTcAMP and SLT muscle from enhancing calcium accumulation. These data demonstrate that SLT muscle target retrogradely regulates calcium accumulation in presynaptic nerve terminals by locally activating presynaptic cAMP-dependent protein kinase.[1]


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