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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.

This is the first isolation and characterization of a cytochrome b5(b5) gene. The bovine b5 gene is quite large, spanning about 28 kb and contains six exons. One of these exons appears to code for a reticulocyte-specific sequence similar to that described for human and rabbit b5. All of the splicing junctions conform to the GT-AG consensus rule. The 5' flanking sequence has no obvious TATA box, two CAAT boxes, and contains several G:C-rich SpI motifs indicative of a house-keeping gene. In reticulocyte mRNA we found evidence for a transcribed b5 pseudogene, but could not detect sequences coding for the soluble form of b5. We conclude that the soluble form of b5 is derived from the membrane-bound b5 by a post-translational mechanism.[1]

References

  1. The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene. Cristiano, R.J., Giordano, S.J., Steggles, A.W. Genomics (1993) [Pubmed]
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