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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Levodopa/carbidopa for childhood amblyopia.

PURPOSE. To evaluate the efficacy and tolerance of two low doses of levodopa/carbidopa (25/6.25 mg, 50/12.5 mg) and placebo (Tums) in 20 children with amblyopia between the ages of 4 and 14 years. METHODS. A double-masked placebo-controlled randomized 8-hour study was performed during which subjects received one of two doses of levodopa/carbidopa or placebo, combined with occlusion of the dominant eye. Visual acuity was measured at baseline and at 1 and 5 hours after capsule ingestion. Tolerance was assessed by questionnaire and physical examination. RESULTS. Visual acuity significantly improved by one line, from an overall average of 20/121 to 20/96, in the amblyopic eyes of both groups that received levodopa/carbidopa. Visual acuity did not significantly change in the placebo group. Tolerance was similar among all three groups. CONCLUSION. Average dose levels of 0.95/0.24 mg/kg and 1.94/0.49 mg/kg of levodopa/carbidopa were found to be well tolerated and efficacious at temporarily improving visual acuity in amblyopic eyes of children.[1]


  1. Levodopa/carbidopa for childhood amblyopia. Leguire, L.E., Rogers, G.L., Bremer, D.L., Walson, P.D., McGregor, M.L. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
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